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Can exercise rewire the brain in people with movement disorders?

NCT ID NCT05002218

Symptom relief Sponsor: Columbia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether balance training or aerobic cycling can improve movement and brain function in 64 people with cerebellar ataxia, a condition that affects coordination. Participants did one type of exercise five times a week for 30 minutes. Researchers used brain scans to see how each exercise affects the brain. The goal is to find which type of training helps more and why.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
balance training and aerobic training on a stationary bike
What this could lead to
If it works, this could point toward better exercise-based therapies to improve walking and coordination in people with cerebellar ataxia.
What could go wrong
This is a small, early-stage study (64 people) that looks at brain changes, not a proven treatment. Results may not apply to everyone with ataxia.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

64 people

The number who actually took part.

Started

Jan 2022

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with spinocerebellar ataxia * Cerebellar atrophy on MRI * Prevalence of ataxia on clinical exam * Ability to safely ride a stationary exercise bike Exclusion Criteria: * Other neurologic conditions * Heart disease * Cognitive impairment * Medical instability

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Conditions

The condition(s) this trial relates to.

Ataxia cerebellar ataxia Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebellar ataxia

Contacts and locations

Locations

  • Columbia University Irving Medical Center

    New York, New York, 10032, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.