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Could a hidden antibody explain liver injury in anorexia?

NCT ID NCT06869590

Knowledge-focused Sponsor: Assistance Publique Hopitaux De Marseille Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study investigates whether certain autoantibodies (anti-HIF1a) are more common in people with anorexia nervosa who also have liver damage. Researchers will compare 100 anorexia patients (with and without liver issues) to 150 control participants, including healthy individuals and those with liver damage from other causes. The goal is to confirm earlier findings and better understand the role of these antibodies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could point toward a new understanding of why some people with anorexia develop liver problems, potentially leading to better monitoring or future treatments.
What could go wrong
This is an early-stage observational study, not a treatment trial. It only looks for a link, so it may not lead to any direct therapy. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

May 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Experimental group: * Male or female, 6 to 65 years of age * Anorexia nervosa diagnosed according to DSM-5 criteria * Presence of undernutrition according to HAS 2019 criteria * Patient having received information about the study and having signed an informed consent form * Beneficiary or beneficiary of a social security scheme Control group: * Minor patients : * Male or female strictly under 18 years of age * Patients undergoing scheduled non-inflammatory surgery (orthopedic, ENT, etc.) * Patients who have been informed about the study and have signed an informed consent form. * Patients who are beneficiaries or entitled beneficiaries of a social security scheme. * Patients without anorexia with livers cytolysis : * Male or female between 18 and 65 years of age * With hepatic cytolysis determined by an ALT value at least equal to twice the normal value * Patient having received information about the study and having signed an informed consent form * Patient who is a beneficiary or eligible beneficiary of a social security scheme. * samples Etablissement Français de don de sang: no specific criteria Exclusion Criteria: * Patient in a period of exclusion from another research protocol at the time consent is signed. * Opposition of patient and parents or legal guardians * Psychiatric disorder preventing patient consent to study * Person unable to understand the French language * Subjects covered by articles L1121-5 to 1121-8 of the French Public Health Code (minors, adults under guardianship or trusteeship, patients deprived of their liberty, pregnant or breast-feeding women).

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Conditions

The condition(s) this trial relates to.

anorexia nervosa

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hepatic cytolysis

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Assistance Publique Hopitaux De Marseille

    RECRUITING

    Marseille, 13005, France

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