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Osteoporosis drug could strengthen knee rebuilds

NCT ID NCT05527548

Disease control Sponsor: Chinese University of Hong Kong Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial tests whether taking alendronate, a drug commonly used for osteoporosis, can improve knee function and stability after anterior cruciate ligament (ACL) reconstruction surgery. About 100 people undergoing their first ACL reconstruction will receive either alendronate or a placebo for a year. Researchers will measure knee stability, bone healing around the graft, muscle strength, and patient-reported symptoms to see if the drug helps recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
alendronate, an oral osteoporosis drug being tested to improve knee healing after ACL reconstruction
What this could lead to
If effective, alendronate could speed up recovery, improve knee stability, and reduce the risk of graft failure after ACL surgery.
What could go wrong
This is a small pilot study, and results may not apply to everyone. Alendronate can cause stomach upset, and its benefit for ACL recovery is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2022

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

14 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male and female with age 14 or above at the time of surgery * First ACLR * Single leg involvement * Able to attend pre-operative assessment * Voluntarily agreed to participate and signed the informed consent form Exclusion Criteria: * Known chronic disease or receiving long-term medications affecting bone metabolism including BPs * Contraindication to alendronate therapy such as poor dental fitness * ACL injury less than 6 weeks * Injury on duty cases * Patients who have undergone arthroscopy or open surgery in the index knee in the last 12 months * Other associated injuries (fractures and other ligament involvement such as neurovascular bundles injury) * Chondral lesion with concomitant intervention * Presence of X-ray features of osteoarthritis including decrease in joint space, presence of osteophytes and subchondral cysts * Neurological deficit * Pregnant or breastfeeding * Inability to give informed consent

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acl reconstruction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Prince of Wales Hospital

    RECRUITING

    Shatin, Hong Kong

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