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Can adding motion release to blood flow training boost ACL healing?

NCT ID NCT07589309

Disease control Sponsor: Green International University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared two rehab approaches after ACL reconstruction: Blood Flow Restriction (BFR) training alone versus BFR combined with Total Motion Release (TMR). 44 participants aged 16-45 did supervised sessions three times a week for six months. The goal was to see if adding TMR improves strength, balance, and knee function more than BFR alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Blood Flow Restriction (BFR) device and Total Motion Release (TMR) procedure
What this could lead to
If successful, this combined approach could speed up recovery of knee strength and balance after ACL surgery, helping people return to normal activities faster.
What could go wrong
This is a small, completed trial with only 44 participants, so results may not apply to everyone. The improvements might be modest or not significantly better than standard rehab.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

44 people

The number who actually took part.

Started

Nov 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 16-45 years. * Both male and female patients. * Underwent primary unilateral ACL reconstruction (hamstring or patellar tendon autograft). * 2-4 weeks post-operative and cleared for supervised rehabilitation. * Willing and able to provide informed consent. Exclusion Criteria: * Revision ACL surgery or multi-ligament injury. * Concomitant fracture or meniscal repair requiring restricted rehab. * History of DVT, vascular disease, uncontrolled hypertension, or cardiovascular disease. * Neurological disorders affecting lower limb strength or balance. * Contraindications to BFR (pregnancy, clotting disorders).

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acl reconstruction Acl-injury

Contacts and locations

Locations

  • Green International University

    Lahore, Punjab Province, 54000, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.