University Of Vermont

This early-phase trial tested whether injecting the chemotherapy drug cisplatin directly into lung tumors (during a bronchoscopy) is safe for people with early-stage, resectable non-small cell lung cancer. Only 6 participants were enrolled, and the main goal was to find the highe…

This pilot study tested whether offering small financial rewards for negative urine tests could help people who use stimulants (like methamphetamine or cocaine) stay abstinent. 27 adults from a syringe exchange program took part. One group could earn money for each clean urine sa…

This study tested whether delivering pre-made meals to the homes of people being treated for opioid use disorder could help with food insecurity. Fifty adults who were getting methadone or buprenorphine and had trouble getting enough food took part. Half got nutrition education a…

This study tested whether offering financial incentives through a smartphone app could help pregnant women stop smoking. 150 women who smoked were randomly assigned to either earn rewards for submitting breath and saliva tests showing no smoking, or to receive standard care. The …

This early-phase trial tested whether MitoQ, a drug that targets cell powerhouses, can improve airway function in 47 obese adults with poorly controlled asthma. Participants took MitoQ or a placebo daily for 12 weeks. The main goal was to see if MitoQ reduces airway reactivity, a…

This study looked at whether giving pregnant smokers cigarettes with very low nicotine helps them smoke less. Thirty women who were less than 25 weeks pregnant and had no college degree took part. Half smoked their usual brand, half got low-nicotine cigarettes, and researchers tr…

This pilot study tested whether a remote digital exercise program (via the Vitala app) is feasible and acceptable for adults with obesity and poorly controlled asthma. Twenty participants followed a tailored exercise prescription for 12 weeks. Researchers measured how many stuck …

This study looked at whether adding a type of talk therapy called prolonged exposure therapy (PET) to standard opioid addiction treatment can help reduce PTSD symptoms. 82 adults with both opioid use disorder and PTSD took part. Some got only addiction treatment, while others als…

This study tested whether a single dose of choline, a nutrient found in foods like eggs, changes brain activity in postmenopausal women. Thirty-eight women aged 50-65 took either choline or a placebo and had their brains scanned with fMRI while doing a memory task. The goal was t…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. The goal was to improve the quality of these conversations by focusing on the patient's values and explaining why CPR may not help. Researchers compared this approach to …

This study looked at why leg muscles shrink and get weaker right after total knee replacement surgery. Researchers studied 23 adults with knee osteoarthritis before and after their operation. They measured muscle fibers, energy-producing parts of cells, and physical activity to f…

This early-phase study looked at how the body handles zinc in people with severe sepsis, a life-threatening infection that causes organ failure. Researchers gave different doses of intravenous zinc to 40 ICU patients on breathing machines and compared them to 15 healthy volunteer…

This study tested whether using gentle electrical pulses to stimulate leg muscles (called NMES) could help older adults recover strength and mobility after being hospitalized for COPD or pneumonia. Seven participants used the device during their hospital stay and for six weeks at…

This study looked at how menopause-related hormone changes affect brain function and Alzheimer's risk in 120 postmenopausal women aged 50-70. Researchers used memory tests and brain scans to see which women's brains coped well with hormone changes and which showed signs of future…