University Of Southern California

This early-phase trial is testing whether a combination of two immunotherapy drugs (botensilimab and balstilimab), a special low-sugar diet that mimics fasting, and high-dose vitamin C is safe and effective for people with a specific type of advanced colorectal cancer (KRAS-mutan…

This study tests a new drug combination (sarilumab plus capecitabine) in people with aggressive breast cancer that has not responded fully to standard treatment. The goal is to eliminate any remaining cancer cells that could cause the disease to spread. The trial involves 65 adul…

This study compares a longer course of Clomid (a fertility drug) to the standard 5-day protocol for ovarian stimulation in women with diminished ovarian reserve undergoing IVF. The goal is to see if the longer protocol can increase the number of mature eggs retrieved while reduci…

This study tests whether a fun digital app (MoodBrush) or parents showing kids how to brush works better at removing plaque. About 112 children aged 3-6 will brush at the dentist, and researchers will measure plaque before and after. The goal is to find an engaging way to improve…

This early-phase trial tests a new drug called AU409 in people with advanced liver cancer or other cancers that have spread to the liver. The main goals are to find the safest dose and see what side effects occur. About 36 adults whose cancer has not responded to standard treatme…

This early-stage trial tests whether a donated bladder can be transplanted using robotic surgery in 5 adults with severe bladder damage. The goal is to see if the transplant works and is safe. Participants will need to take lifelong anti-rejection drugs, so this is a disease-cont…

This study tests whether a gentle massage technique called manual lymphatic drainage (MLD) can reduce swelling, pain, and other side effects in women with early-stage breast cancer who are receiving radiation therapy after breast-conserving surgery. About 50 women will participat…

This study tests whether a weekly injection of tirzepatide can reduce heavy drinking and improve health in 42 adults who have both alcohol use disorder and overweight or obesity. Participants will receive either the drug or a placebo for 8 weeks. The main goal is to see if the dr…

This study surveys 40 adults with non-small cell lung cancer who are already receiving immunotherapy. The goal is to understand how satisfied they are with intravenous (IV) treatment at the hospital versus subcutaneous (SC) injections that could be given at home. Results will hel…

This study is creating a group of 120 to 550 adults with Down syndrome (ages 25-55) who are ready to join future Alzheimer's clinical trials. Researchers will track their thinking skills, genetics, and brain changes over time to find the best ways to measure Alzheimer's progressi…

This study explores whether electrical brain stimulation can be personalized to treat depression symptoms. Researchers will work with 25 epilepsy patients who already have brain electrodes implanted for clinical monitoring. The goal is to develop a system that reads brain activit…

This study aims to understand why some people with liver cancer are diagnosed at a late stage, especially those in low-income areas. Researchers will survey 730 patients about barriers like transportation, food, and housing, and interview doctors and community leaders. The goal i…

This study aims to develop new tools—like skin-like wearable sensors, virtual human conversations, and AI—to better understand mental states such as mood, anxiety, and energy. Researchers will test these tools in 90 healthy adults and epilepsy patients who already have brain elec…

This study looks at whether middle-school students who have gotten in trouble at school can benefit from being trained as peer coaches. The goal is to help them build positive social skills and reduce behavior problems. About 150 students will take part, and researchers will trac…

This study collects blood, tissue, and bone marrow samples from people with cancer, blood disorders, and healthy volunteers. Researchers will use these samples to study how the immune system changes during different treatments, including immunotherapy and chemotherapy. The goal i…

This study looks at cells and biomarkers to understand why head and neck cancer can be aggressive. Researchers will follow 50 newly diagnosed adults who have not yet received treatment. The goal is to learn more about how the cancer grows and returns, not to test a new treatment.

This study collects blood samples and health information from 1,300 women who have had stage I-III breast cancer and finished active treatment. The goal is to create a biorepository—a stored collection of samples and data—that scientists can use in future studies to better unders…

This study surveys 10 adult cancer patients at USC Norris Cancer Center to learn what they know, think, and want from an Integrative Oncology Program. Researchers will use questionnaires to measure interest in therapies like acupuncture, nutrition, and massage, and identify barri…