University Of Southern California

This study tests whether a weekly injection of tirzepatide, a drug used for diabetes and weight loss, can help adults with alcohol use disorder and overweight or obesity reduce heavy drinking. About 42 participants will receive either the drug or a placebo for 8 weeks. The main g…

This study tests a program called FEAST Perinatal Support Program, which helps pregnant women eat healthier and feel better. It is for 40 pregnant adults who qualify for food assistance. The program includes group classes, skill-building, and grocery gift cards to make healthy ea…

This study tests whether a digital app (MoodBrush) or parents demonstrating toothbrushing works better to reduce plaque in children aged 3 to 6. About 112 kids will have their plaque measured before and after brushing. The goal is to find a fun, effective way to improve kids' ora…

This study compares two antibiotics for treating early syphilis: a single penicillin shot (standard care) versus a 14-day course of cefixime pills. Researchers want to see if the pill works just as well. The study includes 400 adults with early syphilis, including those with well…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help people with overweight or obesity quit smoking. 300 smokers will receive either the drug or a placebo, plus nicotine patches, for 16 weeks. The goal is to see if the drug improves quit rates …

This study tests whether a computer-generated character (PERLA) can effectively educate cancer patients about genetic testing, compared to a human genetics counselor. The goal is to make genetic testing more accessible for underserved groups, including racial/ethnic minorities an…

This study tests whether adding 8 weeks of mindfulness training to a single dose of psilocybin (the active ingredient in magic mushrooms) improves mental health more than psilocybin alone. Forty healthy adults who have never used psychedelics or done formal mindfulness training w…

This study looks at how natural changes in estrogen and progesterone during the menstrual cycle affect a woman's readiness for exercise, how hard exercise feels, and recovery after a challenging downhill run. Researchers will measure perceived readiness, muscle soreness, and infl…

This study looks at how depression in older adults (late-life depression) may speed up memory and thinking problems. Researchers will follow 120 participants for 30 months, using brain scans and memory tests. The goal is to understand the link between depression and cognitive dec…

This study compares two types of self-management training for people who have had gastrointestinal (GI) cancer. One group gets a personalized program (RISE-PSMT) and the other gets a standard program (SSMT). The goal is to see which approach helps patients stick to healthy behavi…

This study looks at how people's automatic, hidden feelings about exercise influence whether they stay active. Researchers will use smartphone tests and Fitbit trackers to measure these attitudes in 120 inactive adults who are overweight or obese. The goal is to understand what d…