University Of Rochester

This study looks at whether heart failure patients with a lower risk of dangerous heart rhythms live longer without an implantable defibrillator (ICD) compared to those who get one. About 3,290 adults with reduced heart pumping function will be followed to see who dies or has maj…

This study compares two common bone graft materials (freeze-dried human bone and cow bone with collagen) used to preserve the jawbone after removing a front tooth. About 50 adults who need a front tooth pulled and plan to get a dental implant will be randomly assigned to receive …

This study tests whether daridorexant, a sleep medication, can prevent delirium (sudden confusion) after heart surgery. About 80 adults aged 60 and older having valve or bypass surgery will take either the drug or a placebo for three nights after surgery. Researchers will check f…

This study tests a mobile health exercise program (GO-EXCAP) in 100 older adults (60+) with myeloid neoplasms who are receiving chemotherapy. Participants will either follow the exercise program or receive standard education. The goal is to see if the exercise program improves ph…

This study tests a program called Thrive that helps young adults (ages 18-25) with fetal alcohol spectrum disorders set goals, feel more supported, and improve their quality of life. About 60 participants will be randomly assigned to start the program right away or after a delay.…

This study tests whether reducing loneliness can help people with opioid use disorder. Researchers will enroll 300 adults who feel lonely and have opioid use disorder. Participants will attend six weekly sessions designed to improve social connections. The goal is to see if this …

This study tests whether a compound found in green tea, called EGCG, can reduce frailty and inflammation in older adults who have survived cancer. About 118 people aged 65 and older who have completed cancer treatment will take EGCG or a placebo for 12 weeks. The goal is to see i…

This study tests a program where older adults with advanced cancer and their caregivers talk about meaningful life memories together. The goal is to see if this approach is practical and helps improve emotional well-being and relationship closeness. About 60 patient-caregiver pai…

This study looks at whether adding healthy living strategies to standard blood-thinning medication can improve recovery after a pulmonary embolism (a blood clot in the lungs). About 100 adults who were hospitalized for this condition will join an 8-week program. Researchers will …

This study is testing a non-invasive, acupuncture-like electrical therapy to relieve dry mouth in people who had radiation for head and neck cancer. About 75 adults who finished radiation at least 3 months ago and still have dry mouth will receive the therapy over 12 weeks. Resea…

This study tests whether a small electrical device (TENS) can ease pain during an outpatient procedure for stress urinary incontinence. About 100 women will receive either real TENS or a placebo device during the procedure. The goal is to see if TENS makes the experience less pai…

This early-phase study tests whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration (including retinitis pigmentosa, Stargardt disease, and dry age-related macular degeneration). Researchers believe the drug may…

This study tests whether a supplement from seaweed, called fucoidan, can help reduce fatigue and inflammation in people who have finished cancer treatment. About 40 adult cancer survivors with ongoing fatigue will take the supplement for 8 weeks. Researchers will check if it is p…

This study tests a program called SONATA that helps older adults (65+) with advanced cancer strengthen their social connections. The goal is to see if it improves emotional, social, and overall quality of life. The study will involve 70 participants and compare the program to sta…

This study looks at whether combining PET scans with a blood test that measures tumor DNA can better track how well treatment is working in people with early-stage diffuse large B-cell lymphoma (DLBCL). About 40 adults with untreated limited-stage DLBCL will receive standard chem…

This study aims to understand why myotonic dystrophy type 1 affects people so differently—some have mild symptoms, others severe. Researchers will remotely measure muscle strength, memory, and activity in 1,000 adults, and analyze their DNA from a blood sample. No travel is neede…

This study creates a national registry for people with myotonic dystrophy (DM) or facioscapulohumeral muscular dystrophy (FSHD) and their family members. The goal is to connect patients with researchers to speed up understanding of these inherited muscle-weakening diseases. Parti…

This study looks at how body composition (like weight and body shape) relates to airway tightness and breathing test results in people with asthma or breathing problems. Researchers will use a device called an oscillometer to measure airway resistance. The goal is to better under…

This study tests whether early telehealth visits can help patients with aggressive brain tumors (high-grade glioma) discuss and document their end-of-life wishes soon after diagnosis. About 50 patients and their families will take part in these video or phone visits, guided by a …

This study aims to see if a quick bedside sensory test can help predict which pain medication will work best for people with nerve pain in their feet. About 190 adults with painful peripheral neuropathy will try three different treatments (pregabalin, duloxetine, and a placebo) o…

This study looks for tiny amounts of cancer cells that may remain after treatment for acute myeloid leukemia (AML) or a related bone marrow disorder. Researchers will use special lab tests to see if these leftover cells can predict whether the disease will come back. The goal is …

This study looks at whether sending text messages can encourage people to get screened for lung cancer. Researchers will enroll 40 adults aged 50 to 80 who smoke or have quit within 15 years and are due for screening. Participants will receive texts and be tracked to see if they …

This study tests a communication program called COACH-Cog for older adults who have both dementia and cancer. The goal is to help patients, their care partners, and doctors talk more openly about memory concerns and treatment goals. About 300 people will take part to see if the p…