University Of Rochester

This study compares two common bone graft materials (freeze-dried bone allograft and collagen-enriched cow bone xenograft) used to preserve the jawbone after removing a front tooth. About 50 adults who need a tooth extraction and plan to get a dental implant will be randomly assi…

This study tests whether high-dose vitamin D can prevent bone loss in men aged 50+ with prostate cancer who are receiving hormone therapy (ADT). ADT can weaken bones, raising the risk of fractures. Researchers will give 240 participants either high-dose vitamin D or a placebo for…

This study tests whether adding a kidney nerve procedure (renal denervation) to the standard heart ablation can better control atrial fibrillation (AF) in people with persistent AF who have normal blood pressure or well-controlled high blood pressure. About 50 adults will be rand…

This study tests a combination of two drugs (neratinib and capecitabine) in people with breast cancer that has spread to the brain and is HER2-negative by standard tests but shows abnormal HER2 activity on a special test. The goal is to see if this treatment can help control the …

This study compares two common heart failure medications, carvedilol and metoprolol, in 2,000 adults who have an implantable cardioverter defibrillator (ICD). Participants currently taking metoprolol will be randomly assigned to either stay on it or switch to carvedilol. The goal…

This study tests a program where older adults with advanced cancer and their caregivers talk about their lives together. The goal is to see if this approach is practical and helps improve emotional well-being and relationship quality. About 60 patient-caregiver pairs will be rand…

This study tests whether a mobile health exercise program can improve physical function, reduce fatigue, and enhance mood and quality of life in older adults (age 60+) with myeloid neoplasms who are receiving chemotherapy. About 170 participants will be randomly assigned to eithe…

This study looks at which parts of PTSD therapy work best for children aged 8-17 who have experienced a traumatic event. Researchers will compare different treatment components to a placebo to see what helps reduce symptoms. Participants attend weekly sessions and complete survey…

This study tests a new way for doctors, patients with dementia, and their family caregivers to talk together about cancer treatment decisions. About 300 people (patients with both dementia and cancer, plus their caregivers) will take part. The goal is to see if the communication …

This study tests whether text message reminders can encourage people at high risk for lung cancer to get screened. About 40 participants aged 50 to 80 who smoke or recently quit will receive texts and be followed for 3 months. The goal is to see if this simple approach is practic…

This study looks at why myotonic dystrophy type 1 affects people so differently—some have mild symptoms, others severe. Researchers will measure muscle strength, memory, and activity using tools mailed to your home, plus analyze your DNA from a blood sample. The goal is to find b…

This study looks at how the brains of people with Rett syndrome respond to sound. About 60 participants will wear a noninvasive EEG cap while listening to simple sounds. Parents or caregivers will also answer questions about symptoms and daily life. The goal is to better understa…

This study aims to develop tests that find tiny amounts of cancer cells left in the body after treatment for acute myeloid leukemia (AML) or high-grade myelodysplastic syndrome (MDS). By analyzing bone marrow samples, researchers hope to identify patients at higher risk of their …