University Hospitals, Leicester

This study looks at 40 adults aged 50 to 75 with large rotator cuff tears. Half get standard surgery, and half get surgery plus a human skin patch. The goal is to see if the patch lowers the chance of the tendon tearing again one year later. Participants will have MRI scans and c…

This study compares a new pacing technique (His bundle pacing) to standard right ventricular pacing in 100 adults with symptomatic atrial fibrillation and heart failure who are having AV node ablation. The goal is to see if the new method helps them walk farther, feel better, and…

This study tests a blood filter called HA380 in 40 critically ill adults (ages 18-65) who need dialysis or ECMO due to severe infection, injury, or major surgery. The filter is added to their life-support circuit to remove inflammatory substances from the blood. Researchers want …

This study aims to understand why breathlessness varies among people with different lung diseases like COPD, asthma, and ILD. Researchers will measure lung function, exercise ability, and breathing patterns in 75 participants (50 with lung disease and 25 healthy controls). The go…

This study is testing a simple bedside device called a bioimpedance analyser to measure body water changes in pregnant women. Researchers will compare its readings to standard fluid charts in 900 women, including those having planned C-sections, induced labor, or conditions like …

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future.…

This study aims to find the genetic causes of bicuspid aortic valve (BAV), a common heart defect where the valve has two flaps instead of three. Researchers will collect blood samples from 700 people with BAV and their family members to compare DNA. The goal is to identify gene c…