University Hospitals, Leicester

This study looks at whether adding a human skin patch to rotator cuff repair surgery can reduce the chance of the tendon tearing again. About 40 adults aged 50 to 75 with large tears will be randomly assigned to get either standard repair or repair with a patch. All participants …

This study aims to understand why breathlessness feels different in various lung diseases like COPD, asthma, and ILD. Researchers will measure lung function, exercise ability, and breathing patterns in 75 people (50 with lung disease and 25 healthy). The goal is to gather detaile…

This study aims to find the genetic causes of bicuspid aortic valve (BAV), a common heart condition where the valve has two flaps instead of three. Researchers will collect blood samples from 700 people with BAV and their relatives to compare DNA. The goal is to identify gene cha…

This study enrolls 9,500 adults with various heart and blood vessel conditions, plus healthy volunteers, to collect medical details and samples over 20 years. Researchers will analyze proteins, chemicals, and genes to improve how doctors diagnose heart disease and predict future …