Uconn Health

This study tests whether adding a second thyroid hormone (liothyronine) to the standard levothyroxine treatment can improve cholesterol levels and quality of life in people with hypothyroidism. About 90 adults who already take levothyroxine will be randomly assigned to one of thr…

This study tests whether a newer FDA-approved contrast agent, Gadopiclenol, provides clearer images of pituitary lesions on MRI compared to the standard agent, Gadobutrol. Ten adults with known or suspected pituitary lesions will receive both agents in random order, with neither …

This study explores whether computerized brain-training exercises can help older adults (age 60+) with Long COVID improve their thinking, mood, and daily functioning. Researchers will test if the program is easy to use and acceptable to participants. The goal is to gather early e…

This study tests whether a supplement called MitoQ can improve blood vessel health, physical mobility, and thinking skills in frail older adults aged 65 to 80. Participants take MitoQ or a placebo for a period, and researchers measure changes in walking speed, memory, and blood f…

This study aims to find the genes that cause keloid scars, which are thick, raised scars that grow beyond the original wound. Researchers will collect DNA from up to 7,000 people with keloids and their family members. The goal is to understand why some people develop keloids and …

This study looks at how young adults and their friends influence each other's health behaviors. Participants will complete questionnaires, take part in a short health program with a peer, and have a brain scan. Researchers will follow up at 3, 6, and 12 months to see if brain act…

This study aims to find the genes that cause craniometaphyseal dysplasia (CMD), a rare bone disorder. Researchers will analyze blood and tissue samples from up to 600 people, including affected individuals and their family members. The goal is to understand the disease better and…

This research study aims to find the genes and genetic changes that cause aplasia cutis congenita (ACC), a rare condition where skin is missing at birth. Researchers will study DNA and tissue samples from up to 600 people with ACC and their family members. The goal is to better u…

This study aims to find the genes and genetic changes that cause cherubism, a rare condition that affects the jawbones. Researchers will study blood and tissue samples from up to 600 people, including patients and their family members. The long-term goal is to understand the dise…

This study involves 30 adults with a type of heart failure called HFpEF. Participants will stop taking their beta-blocker medication for 4 weeks. Researchers will measure changes in heart function, exercise ability, and quality of life to learn more about the effects of stopping …

This study looks at whether collecting sperm after just one hour of abstinence (instead of the usual 2-5 days) results in embryos with normal chromosomes during IVF. About 187 couples with infertility will each provide sperm after both short and standard abstinence, and the embry…