The University Of Texas Health Science Center, Houston

This trial tests two different types of drugs—an IL-17 inhibitor (secukinumab) and a JAK inhibitor (upadacitinib)—in people with axial spondyloarthritis who have not improved with a TNF inhibitor. The goal is to see which approach is more effective at reducing disease activity ov…

This study tests whether making a small venting hole in the femur before inserting a stabilizing rod can reduce the number of fat or bone marrow emboli that travel to the heart and lungs during surgery. It includes 10 people with impending femur fractures who need prophylactic in…

This study tests whether combining repetitive transcranial magnetic stimulation (rTMS) with cognitive training games can strengthen brain connections in people with schizophrenia. Participants will receive either active or sham rTMS sessions along with computer-based cognitive ex…

This study explores whether virtual group medical appointments focused on lifestyle changes can help people with high blood pressure lower their readings. Participants attend four online sessions over eight weeks, track their blood pressure at home, and get medication adjustments…

This study tests whether adding a simple stitch to support the top of the vagina during a scarless hysterectomy (vNOTES) can help prevent pelvic organ prolapse later on. Fifty women having a vNOTES hysterectomy for non-cancer reasons will be enrolled. The surgeons will measure va…

This study will test a rapid fingerstick test for HIV and syphilis in pregnant women who come to the emergency department without prior prenatal care. Researchers want to see if offering this test leads to more women being diagnosed and starting treatment right away. The goal is …

This study tests whether a 16-week family-based psychosocial intervention can reduce persistent and distressing psychotic-like experiences in children and young adults who have a family history of schizophrenia spectrum disorders (SSD). Participants and their caregivers will atte…

This study looks at ways to improve care for teens and young adults who have experienced sexual assault. The goal is to offer same-day HIV prevention medicine and substance use support during their emergency room visit. Researchers will work with young people to design and test t…

This study tests whether giving high-risk pregnant women free deliveries of fresh produce, lean protein, and whole grains—plus nutrition classes—can prevent gestational diabetes. Researchers will enroll 400 women receiving care at Harris Health clinics who are early in pregnancy …

This study tests a stepped-care version of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) for children with elevated traumatic stress symptoms. The therapy is delivered in pediatric primary care, with intensity matched to each child's needs and caregiver involvement. Resear…

This study tests whether a program of weekly phone calls from a trained team member can reduce loneliness and social isolation in older adults. Participants will receive 90 days of mostly unstructured calls, supported by conversation guides. The study will assess how feasible the…

This study tests a device called BreEStim that uses electrical stimulation timed with your breathing to reduce nerve pain after spinal cord injury. About 66 adults with long-term spinal cord injury and stable pain will receive either active or sham treatment. The goal is to see i…

This trial tests whether a non-invasive device that gently stimulates the vagus nerve through the ear is tolerable for children who have had a stroke. One child will receive ear stimulation paired with occupational therapy sessions over four weeks. The goal is to see if the child…

This pilot study tests whether zavegepant nasal spray can quickly relieve pain from episodic cluster headaches. About 40 adults with episodic cluster headaches will use the spray at the start of an attack. The main goal is to see how many achieve minimal or no pain within 30 minu…

This early-phase trial investigates whether injecting collagenase—an enzyme that breaks down collagen—can reduce spasticity (muscle tightness) in people who have had a stroke, brain injury, or spinal cord injury. The study enrolls 15 adults who are at least six months post-injury…

This trial tests whether injecting collagenase—an enzyme that breaks down tough connective tissue—can reduce contracture (stiff, shortened muscles) and spasticity (uncontrolled muscle tightness) in people with neurological impairments like stroke, brain injury, or spinal cord inj…

This study tests a therapy called Mentalizing Imagery Therapy (MIT) for family caregivers of people with Alzheimer's or related dementias. The goal is to see if it can lower stress, depression, and the risk of elder mistreatment. About 50 caregivers who provide at least 8 hours o…

This study tests whether a virtual home rehabilitation program helps stroke survivors in underserved Texas communities recover better than standard care alone. About 80 adults who recently had a stroke and are returning home will take part. The program uses video sessions to guid…

This study tests a daily testosterone gel to see if it can safely improve sexual interest and arousal in women going through menopause. Researchers will compare the gel to a placebo in 150 women aged 40-65 who have been diagnosed with low sexual desire. The goal is to provide a m…

This study tests a personalized version of a therapy called Stepped Care Cognitive Behavioral Therapy for children who have experienced trauma. The therapy is adapted for Latino families and involves caregivers helping their children through a step-by-step process. Researchers wi…

This pilot study tests a personalized version of stepped-care cognitive behavioral therapy for PTSD in Latino children aged 7-12. The therapy involves a caregiver-led first step with therapist support, followed by more intensive therapy if needed. The goal is to see if adapting t…

This study looks at whether a procedure called microneedling radiofrequency (which uses tiny needles and heat) can improve skin and fat thickness in the face, and if adding a topical cream (poly-L-lactic acid) makes it work better. About 30 adults seeking facial rejuvenation will…

This study will test a mobile app called ¡Iniciando! designed to help Latino young adults with autism and their families navigate the move to adulthood. The app includes virtual group sessions and coaching over 12 weeks. The goal is to see if the app is easy to use, acceptable, a…

This study tests whether brief informational 'nudges' can improve financial decision-making in older adults who are vulnerable to exploitation. Participants aged 60 and older will review simple strategies before completing money-related tasks that measure risk-taking, trust, pati…

This study investigates how older adults make financial decisions, especially those who may be vulnerable to exploitation. Researchers will use computer-based tasks with real monetary rewards to measure risk tolerance, trust, altruism, patience, and loss aversion. Some participan…

This study tests a simple screening tool to help doctors find muscle stiffness (spasticity) sooner after a stroke. Researchers will track how quickly spasticity is detected and whether the tool helps doctors make faster treatment decisions. About 80 adults who recently had a stro…

This study looks at how often people develop allergic skin reactions to two different wound dressings used after open shoulder surgery: one made from silk protein and another from a medical glue mesh. About 350 adults having shoulder surgery will be randomly assigned to one dress…

This study looks at whether a program called MAGIC, which adds short physical activity breaks and lessons into the school day, can help elementary students be more active and lower their risk for heart problems. Researchers will track how well teachers use the program and measure…

This study will test an online tool called iCHAMPS-YVP that helps Texas school staff choose and put into practice proven programs to prevent bullying and teen dating violence. Researchers will work with 25 school administrators, teachers, and counselors to see if the tool is easy…

This pilot study will test whether an artificial intelligence tool can give helpful feedback to medical residents about how they talk with patients. Sixty-four surgery residents will have their conversations with actors playing patients recorded and analyzed by a large language m…

This study will test a device called GentleWave that is designed to clean root canals more effectively, especially in hard-to-reach areas. Researchers will use 50 teeth that are already scheduled for extraction. After a partial root canal treatment with GentleWave, the teeth will…