The First Hospital Of Jilin University

This study tests whether adding the immunotherapy drug sintilimab to standard chemotherapy can help prevent a rare type of skin cancer (mucosal melanoma) from coming back after surgery. About 220 adults with PD-L1-positive, completely removed tumors will be randomly assigned to g…

This trial tests whether a modified feeding protocol, guided by a predictive model of feeding intolerance, can reduce digestive problems in critically ill patients. The study will enroll 2,250 adults in ICUs across 90 hospitals, with each hospital randomly assigned to use the new…

This trial tests a split-type robotic system for removing Siewert type II/III gastroesophageal junction cancer, a tumor at the junction of the esophagus and stomach. The study will enroll 25 patients who need curative surgery. Researchers will measure how often the robotic proced…

This study looks at whether robotic-assisted surgery using a vessel sealer can improve outcomes for people with locally advanced stomach cancer. The vessel sealer is a tool that cuts and seals blood vessels with less heat damage than older devices. Researchers will track 300 pati…

This study follows 90 adults with upper stomach or gastroesophageal junction cancer who undergo proximal gastrectomy, a surgery that removes the upper part of the stomach. Researchers compare different ways to reconnect the digestive tract, such as double-tract reconstruction or …

This study tests a new combination of drugs for people with advanced colorectal cancer that has stopped responding to initial treatment. About 30 adults aged 18-75 will receive a mix of chemotherapy and targeted therapy. The goal is to see if this approach can delay cancer growth…

This study tests a new type of CAR-T cell therapy, boosted with IL-15, in 25 people with multiple myeloma or plasma cell leukemia that has come back or not responded to treatment. The therapy uses the patient's own immune cells, engineered to target cancer cells. The goal is to s…

This study tests whether adding a targeted drug (surufatinib) to a standard pre-surgery regimen of short-course radiation, chemotherapy, and immunotherapy (toripalimab) can improve outcomes for people with high-risk mid-to-low rectal cancer. About 212 participants will receive on…

This study tests a new drug called CapsuleX combined with cisplatin in 40 people whose ovarian cancer no longer responds to platinum-based chemotherapy. The goal is to see if the combination can shrink tumors and how safe it is. Participants must have confirmed ovarian, fallopian…

This study tests whether daphnetin capsules, made from a daphne plant extract, can improve outcomes when combined with standard chemotherapy (TC regimen) for stage III-IV epithelial ovarian cancer. About 98 participants who had initial surgery will receive the combination, then c…

This study tests whether a special delayed-connection surgery (Turnbull-Cutait) can help people with low rectal cancer avoid a permanent colostomy bag better than the standard surgery with a temporary stoma. About 520 adults aged 18-75 with rectal cancer will be randomly assigned…

This study is testing whether a liquid called Paiteling, applied directly to the cervix, can clear persistent high-risk HPV infections. The trial will enroll 115 women aged 25 to 65 who have had the same high-risk HPV type for at least two years. Researchers will check if the vir…

This study tests whether giving the blood thinner tirofiban soon after standard clot-busting medication helps people recover better from a stroke. About 1,084 adults with moderate stroke symptoms will receive either tirofiban or a placebo within 6 hours of the initial treatment. …

This study tests whether an artificial intelligence (AI) smartphone app can help people with type 2 diabetes control their blood sugar better than regular doctor visits. About 400 adults will either use the AI app to get personalized diet, exercise, and medication advice, or rece…

This study tests whether combining budesonide (Nefecon) and ambrisentan can reduce protein in the urine and preserve kidney function in people with IgA nephropathy who are at risk of kidney failure. About 129 adults will take both pills daily for 36 weeks. Researchers will measur…

This study is testing a new, non-invasive way to detect high-risk varices (enlarged veins) in the esophagus and stomach of people with liver cirrhosis. Instead of using a camera down the throat (endoscopy), doctors will use a special ultrasound technique called SHAPE, along with …

This study follows 160 critically ill ICU patients who need tube feeding. Researchers will take blood samples and use ultrasound to measure stomach muscle activity before feeding starts. They will then track whether patients develop feeding intolerance within 7 days. The goal is …

This study is looking for factors that might predict inflammatory polyps in the ureter (the tube from kidney to bladder) in people with kidney stones. Researchers will review past patient data and then test their predictions on new patients. The goal is to create a simple tool th…

This study follows 900 people having lung cancer surgery to learn why some develop blood clots in their legs (deep vein thrombosis) within 30 days after surgery. Researchers will collect medical data and use machine learning to build a tool that predicts each person's risk. The g…

This observational study looks at proteins in tiny particles called extracellular vesicles from the blood of 120 people with brain aneurysms. Researchers will collect blood from different areas of the circulatory system during surgery to compare protein patterns. The goal is to f…

This study looks at whether lowering the amount of liquid food given through a tube before turning a patient onto their stomach (prone position) can reduce stomach problems like bloating or vomiting. The study involves 259 adults in the ICU who are on breathing machines for sever…