Technische Universität Dresden

This study tests two chemotherapy drugs, treosulfan and melphalan, given before a stem cell transplant in 220 adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The goal is to see which drug works better at helping patients survive longer with fewer side …

This phase 1 trial tests an experimental therapy called MDC-CAR-BCMA001 in adults with relapsed or refractory B-cell cancers, including multiple myeloma and diffuse large B-cell lymphoma. The treatment uses a patient's own immune cells, modified to target a protein called BCMA on…

This trial tests whether a combination of venetoclax and azacitidine can work as well as or better than standard intensive chemotherapy for adults with newly diagnosed acute myeloid leukemia that has an NPM1 mutation. Participants are aged 18 to 70 and healthy enough for intensiv…

This phase II trial is testing whether the drug ivosidenib, taken as a pill, can help prevent relapse in people with acute myeloid leukemia (AML) or myelodysplastic neoplasia (MDS) who have an IDH1 mutation and have recently undergone a stem cell transplant. Participants will sta…

This study compares two surgical approaches for people with pancreatic cancer who are at high risk for a serious complication called a pancreatic fistula. One group gets the standard surgery that removes only the tumor-affected part of the pancreas. The other group has the entire…

This study is testing whether a lower dose of radiation after surgery can safely treat HPV-positive head and neck cancer while reducing long-term side effects. About 304 participants will receive either standard or reduced radiation, with or without chemotherapy. The goal is to s…

This study is testing whether adding two targeted drugs, midostaurin and gemtuzumab ozogamicin, to standard chemotherapy can help people with newly diagnosed acute myeloid leukemia (AML) who have certain genetic changes. About 214 participants will receive the combination in two …

Researchers at a German university eye hospital collect and anonymize data from about 10,000 people with glaucoma, ocular hypertension, or suspected glaucoma. They study how often patients should return for check-ups and which treatments best lower eye pressure for each person. T…

This study tests whether tumor organoids grown from biopsies can predict how well patients with gastric or colon cancer and peritoneal carcinomatosis respond to hyperthermic intraperitoneal chemotherapy (HIPEC). Researchers collect tumor samples during standard surgery, grow them…

This study follows 500 people who have surgery to remove the rectum, a procedure called rectal resection. Researchers want to see how bowel and bladder function change before and after the operation, using questionnaires and pressure measurements. They will track patients for up …

This first-in-human study tests a machine learning system that provides real-time guidance during robot-assisted rectal cancer surgery. The system aims to help surgeons by predicting the correct surgical plane. Twelve patients with rectal cancer will be enrolled to see if the tec…

Researchers are evaluating a flexible and integrative psychiatric care model at Pfalzklinikum in Germany. The model uses a global treatment budget to allow more outpatient and fewer inpatient treatments. The study compares outcomes like hospital stay duration and sick leave days …

This study follows 150 patients who have had part of their pancreas removed. Researchers will measure blood levels of amylase and lipase before, during, and after surgery to see if high levels can predict serious complications like pancreatitis. The goal is to improve how doctors…

This trial tests whether wearable devices like smartwatches can measure blood pressure as accurately as standard arm cuffs or invasive arterial lines. Hospitalized patients will wear multiple devices using light-based (PPG) and wrist-cuff methods, with readings compared to clinic…

This study tests a new AI system called IntelliLung that suggests ventilator settings for ICU patients on breathing machines. Researchers will compare how often doctors' settings match the AI's recommendations. About 530 adults on ventilators will take part across multiple hospit…

This study is building a national registry of 500 adults with VEXAS syndrome, a rare inflammatory disease. Researchers will collect medical information and biological samples during routine care to learn more about how the disease behaves, what treatments work best, and how to di…

This study looks at past treatment data from over 300,000 ICU patients who needed a breathing machine (ventilator). The goal is to train an artificial intelligence (AI) system to help doctors choose the safest ventilator settings. By learning from real-life decisions and patient …

This registry study is collecting medical information and biological samples from 15,000 adults with acute myeloid leukemia (AML) across 60 German hospitals. Researchers aim to track patient outcomes, treatment patterns, and disease characteristics to better understand AML. No ne…

This study is developing and testing computer-assisted guidance tools that work with real-time imaging (like ultrasound or CT) during abdominal surgery. About 40 adults having laparoscopic, robotic, or open surgery will take part. The main goal is to see if the technology works w…

This study aims to learn about the quality of life, medical care experiences, and unmet needs of people who have lived with sarcoma for at least five years. Researchers will survey 1,600 survivors in Germany and interview up to 60 of them in depth. The goal is to identify what su…