Supernus Pharmaceuticals, Inc.

This study tested a drug called SAGE-547 in 25 people with super-refractory status epilepticus, a life-threatening condition where seizures don't stop even with strong medications. The main goal was to see if the drug was safe and tolerable when added to standard treatment. The s…

This study tested a drug called SAGE-547 in 132 people with super-refractory status epilepticus, a life-threatening condition where seizures don't stop even with strong anesthetics. The goal was to see if SAGE-547 could help patients come off these anesthetics and stay seizure-fr…

This study tested a drug called SAGE-718 in 69 people with early Huntington's disease to see if it could improve thinking and daily functioning. Participants took the drug or a placebo for 28 days. The main goal was to measure changes in cognitive abilities like memory and proble…

This study tested an experimental drug called SAGE-718 in 174 people with mild memory problems or mild dementia caused by Alzheimer's disease. The main goal was to see if the drug could improve thinking skills, especially processing speed, compared to a placebo. The trial has bee…

This early study tested a drug called SAGE-718 in 18 people with Parkinson's disease who also have mild problems with memory and thinking. The main goal was to see if the drug is safe and tolerable. Researchers also looked at whether it helped with thinking, mood, and movement. T…

This study tested a medicine called SAGE-547 given as a 60-hour IV drip to help women with moderate to severe postpartum depression. 108 women took part. The goal was to see if the drug could quickly lower depression scores compared to a placebo. Results showed improvement in dep…

This study looked at whether Qelbree (SPN-812) can help adults with both ADHD and mood symptoms. 161 people took part and received the drug in an open-label, flexible-dose design. Researchers tracked changes in ADHD symptoms using a standard rating scale. The goal was to see if s…

This study tested an experimental drug called SAGE-547 in 21 women with severe postpartum depression. The goal was to see if a single injection could quickly reduce depression symptoms compared to a placebo. The trial was small and early-stage, focusing on safety and how well the…

This study tested a drug called SPN-810 in 78 children aged 6 to 12 with ADHD and serious conduct problems. The main goal was to see if different doses of the drug are safe and tolerable. Researchers measured behavior changes using a special rating scale. The study was completed …

This study tested an experimental drug called SAGE-547 in 138 women with severe postpartum depression. The drug was given as a 60-hour IV infusion to see if it could quickly reduce depression symptoms compared to a placebo. The goal was to help new mothers feel better without lon…

This study tested an experimental drug, SAGE-718, to see if it could improve thinking skills like memory, attention, and processing speed in people with Huntington's disease. About 189 adults with early to moderate Huntington's took either the drug or a placebo for a set time. Th…

This study tested a new drug called SAGE-718 in 26 people with mild memory or thinking problems due to Alzheimer's disease. The main goal was to see if the drug is safe and tolerable, and to check if it helps with cognitive and mood symptoms. Participants took the drug and were m…

This early study tested a single 6-hour intravenous dose of brexanolone in 10 adults with tinnitus to see if it is safe and could reduce the perceived loudness of ringing in the ears. The main goal was safety, with a secondary look at symptom changes. Results are not yet availabl…

This early study tested an experimental drug called SAGE-547 in 4 women with severe postpartum depression. The main goal was to check if the drug is safe and how the body processes it. Results are limited due to the very small number of participants, but the study helps lay the g…

This study tested an experimental drug called SAGE-718 to see if it could improve thinking and memory in people with Parkinson's disease who have mild cognitive impairment. 86 participants took either the drug or a placebo. The main goal was to measure changes in processing speed…

This study tested a drug called brexanolone in teenage girls who had depression after giving birth. The goal was to see if the drug was safe and how the body processes it. 28 participants were enrolled, and the study is now complete.

This study looked at whether the drug ZULRESSO (brexanolone) can be safely given to women with postpartum depression in their own homes instead of a clinic. Fifty-two women took part, and researchers tracked side effects and whether the safety rules were followed. The goal was to…

This early-stage study tested an experimental drug called SAGE-718 in 40 healthy adults. Researchers used a ketamine challenge to see how the drug affects brain electrical activity and safety. The goal was not to treat any disease, but to gather information for future research.

This early-stage study tested an experimental drug called SAGE-718 in 19 healthy adults to see how it affects brain chemicals when combined with ketamine. Participants received both the drug and a placebo at different times, and brain scans measured changes in key chemicals. The …

This early-stage study tested an experimental drug called SAGE-904 in 22 healthy adults to see how it affects brain electrical activity. Participants received either the drug or a placebo, then were given ketamine to temporarily mimic certain brain changes. The goal was to measur…

This early-stage study tested the safety and tolerability of an experimental drug called SAGE-718 in 6 people: healthy adults and patients with Huntington's disease. The main goal was to check for side effects and how the drug moves through the body. It was a Phase 1 trial, meani…

This early-stage study tested a single dose of the experimental drug SAGE-718 in 22 healthy adults. Researchers used a ketamine challenge to see how the drug affects brain electrical activity, safety, and how the body processes it. The goal was to gather information, not to treat…