Stony Brook University

This study aims to find better ways to treat depression in people with chronic kidney disease (CKD). About 201 adults with advanced CKD and major depression will receive either behavioral activation therapy, a different antidepressant (bupropion), or a placebo, with the option to…

This early-phase study tests whether combining targeted radiation with an immunotherapy drug (atezolizumab) before surgery can help control glioblastoma, a fast-growing brain cancer. Twelve newly diagnosed patients will receive two weeks of treatment, then undergo standard surger…

This study tests a brief motivational program to help 84 cancer survivors from the World Trade Center Health Program increase their physical activity. Participants will wear a Fitbit to track activity, and the goal is a 25% boost in moderate-to-vigorous exercise. The program focu…

This study looks at whether coloring nature or geometric shapes can help adults feel less pain and anxiety while waiting in the emergency department. About 168 people with moderate pain or anxiety will be asked to color and then report how they feel. The goal is to find a simple,…

This study tests whether a nerve block can help people who have neck surgery use fewer opioid painkillers and feel less pain. About 60 adults having posterior cervical spine surgery will be randomly assigned to receive either the nerve block plus standard pain medication or stand…

This study compares using a Foley balloon plus misoprostol to standard osmotic dilators (Laminaria) for preparing the cervix before a second-trimester surgical abortion (D&E) between 16 and 21 weeks. About 102 women in Mozambique will take part. The goal is to see if the balloon …

This early study tests a non-invasive device that sends gentle pulses to a nerve in the ear, aiming to safely reduce delirium (sudden confusion) in ICU patients. Ten adults with delirium will receive 30-minute sessions twice daily for up to 7 days, alongside usual care. Researche…

This study looks at how different energy sources—glucose and ketones—change brain activity in people with bipolar disorder. About 100 participants will have MRI scans while playing money-winning games, before and after drinking glucose or ketones. Researchers want to see if the b…

This study looks at how fear and anxiety about anesthesia change in people who have never had it before. About 40 adults scheduled for low-risk surgeries will fill out surveys before their procedure and answer follow-up questions a few days later. The goal is to understand if the…

This study tests a new computer tool called SeeMe that can detect very small movements in people with severe traumatic brain injury. Current exams may miss these movements, leading to misdiagnosis. The tool uses cameras and AI to spot responses to commands, which could help docto…

This study is testing a decision aid for people with small thyroid nodules that are either cancerous or have a chance of being cancerous. The goal is to see if the tool helps patients choose a treatment that aligns with their personal values. Participants will fill out surveys be…

This study looks at how a brain protein called mGluR5 might help explain why cognitive behavioral therapy for insomnia (CBT-I) can also improve depression. Researchers will measure changes in this receptor and sleep patterns in 42 adults with major depression and insomnia. The go…