St. Joseph's Hospital And Medical Center, Phoenix

This Phase II trial tests whether siponimod, a drug already approved for multiple sclerosis, can safely slow brain atrophy in people with mild Alzheimer's disease. Over 18 months, 105 participants will receive either the drug or a placebo. Researchers will measure brain volume ch…

This study tests an experimental drug called BDTX-1535 in people with aggressive brain tumors (high-grade glioma or glioblastoma) that have certain changes in the EGFR gene. The drug aims to block a growth signal that these tumors rely on. The trial first measures how much drug r…

This study is gathering medical information, blood samples, and speech recordings from 2,000 people with ALS and healthy volunteers over two years. The goal is to create a shared resource that scientists can use to better understand ALS and develop new treatments. Participants ca…

This study follows 600 adults who are genetically at risk for ALS due to family history. Over three years, researchers collect blood samples, speech recordings, and health data to track early signs of the disease. The goal is to build a rich database that scientists can use to be…