St. Joseph's Hospital And Medical Center, Phoenix

This study tests whether siponimod, a drug already used for multiple sclerosis, can safely slow brain shrinkage in people with mild Alzheimer's disease. About 105 participants will receive either the drug or a placebo for 12 months, then be monitored for another 6 months. The mai…

This study tests an experimental drug called BDTX-1535 in people with aggressive brain tumors (high-grade glioma or glioblastoma) that have certain changes in the EGFR gene. The drug aims to block a growth signal that these tumors rely on. The trial first measures how much drug r…

This study is gathering medical information, blood samples, and voice recordings from 2,000 people with ALS and healthy volunteers over two years. The goal is to create a large database for researchers to better understand ALS and related diseases. No experimental treatments are …

This study is for adults who have a close family member with ALS or carry a gene linked to the disease, even if they have no symptoms. Researchers will collect blood samples, medical history, and speech recordings over three years to track early changes. The goal is to better und…