Shanghai Mental Health Center

This trial tests whether a non-invasive brain stimulation technique called HD-tACS can reduce alcohol cravings and help prevent relapse in people with alcohol use disorder. Participants receive either real or sham stimulation for 20 minutes, three times a day, over 10 days. Resea…

This trial tests whether a non-invasive brain stimulation technique, called transcranial temporal interference stimulation, can reduce drug cravings in people with methamphetamine use disorder. The stimulation targets the nucleus accumbens, a brain region involved in reward and a…

This trial is testing whether two types of brain stimulation can reduce symptoms in people with treatment-resistant major depressive disorder—depression that hasn't improved after trying standard antidepressants. One approach uses a surgically implanted device that delivers elect…

This trial tests whether a lightweight, wearable brain stimulation device, called rTMS-Tiny, can be used safely and effectively at home to treat major depressive disorder. The device delivers magnetic pulses to the brain, similar to standard TMS therapy, but is designed to be por…

This pilot trial tests whether a personalized brain stimulation technique can help people with methamphetamine use disorder. The approach uses closed-loop theta-burst stimulation, which delivers magnetic pulses to a specific brain region in real time, triggered by the person's ow…

This trial investigates whether a gamified eye-movement training program can improve cognitive function in people across different stages of schizophrenia, including those at clinical high risk. Participants will be randomly assigned to either eye-movement training or a finger-co…

This study tests whether a gentle electrical stimulation of a nerve in the ear (called taVNS) can help people who are dependent on the drug tiletamine. Thirty participants will receive either real or sham stimulation over five days. Researchers will measure changes in cravings, m…

This early-stage study tests whether a nasal spray containing particles from neural stem cells is safe for people with moderate-to-severe early-onset Alzheimer's. Nine participants aged 50-75 will receive different dosing schedules over 28 days. The main goal is to check for side…

This study tests a non-invasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) aimed at the amygdala, a brain region linked to cravings. Researchers will enroll 60 adults with alcohol use disorder to see if tTIS can reduce alcohol craving…

This pilot study will test whether a high-intensity brain stimulation device can help people with alcohol use disorder reduce their cravings and drinking. Eighteen adults will receive 20 sessions of stimulation over 10 days. Researchers will measure changes in cravings, drinking …

This study is developing a computer-assisted tool that uses a camera to objectively measure movement problems caused by antipsychotic medications. Researchers will enroll 180 people—half with these movement disorders and half healthy—to see how well the tool's results match stand…

This study will check if an artificial intelligence (AI) system can diagnose depression as accurately as a psychiatrist. About 100 adults with depression will take part. Their AI-based diagnosis will be compared to the diagnosis made by a mental health specialist.

This study will test whether an artificial intelligence (AI) system can diagnose anxiety disorders as accurately as a psychiatrist. One hundred adults with anxiety will be assessed by both the AI and a specialist, and the results will be compared. The goal is to see if the AI is …

This study tests a new type of transcranial magnetic stimulation (TMS) that targets three brain areas at once to help with negative symptoms of schizophrenia, like lack of motivation, emotion, or social interest. Researchers will enroll 64 people with first-episode schizophrenia …

Researchers test whether transcutaneous electrical acupoint stimulation, a non-invasive way to stimulate acupuncture points, adds benefit to exposure and response prevention therapy for adults with obsessive-compulsive disorder. The trial enrolls 90 people aged 18 to 50 with mode…

This trial investigates whether a traditional Chinese medicine formula, Xingqi Daozhi Decoction, can relieve constipation that often occurs as a side effect of antipsychotic medications in people with schizophrenia. The study will enroll 46 adults with schizophrenia who have deve…

This study tests whether gentle ultrasound waves aimed at the brain can help with memory and thinking problems in people with schizophrenia. 140 adults with stable schizophrenia will receive either real or fake ultrasound sessions over 20 days. Researchers will check if memory an…

This study tests whether an AI-based rehabilitation program, combined with usual care, can reduce anxiety symptoms more than usual care alone. About 158 adults with anxiety disorders will use the AI system for 12 sessions over 3 weeks. The goal is to see if digital therapy can im…

Researchers at Shanghai Mental Health Center are following 500 people with obsessive-compulsive disorder to see how symptoms, daily functioning, and treatment responses change over time. The study includes adults aged 18 to 60, including some who have never received OCD treatment…

This clinical trial is testing a medical device that has not yet been approved by the U.S. FDA. Because the trial details are withheld, the exact purpose, participants, and approach are not publicly known. The study is likely gathering early information on the device's safety and…

This study follows 400 adults with generalized anxiety disorder (GAD) to understand how symptoms and health change over time. Researchers will collect clinical assessments, blood samples, and brain measurements at multiple visits. The goal is to identify factors that may predict …

This study follows 200 children and teens aged 7-17 who are at higher risk for depression, anxiety, or obsessive-compulsive disorder (OCD) due to family history or early symptoms. Over two years, researchers will use interviews, questionnaires, brain scans (EEG and MRI), and biol…

This study aims to develop models that combine clinical assessments with biological data (multi-omics) to improve diagnosis of major depressive disorder and predict how patients will respond to antidepressants. Researchers will follow 150 participants aged 14-45 with depression, …

This study looks at 130 people with major depression who have suicidal thoughts. Researchers will use brain scans, genetic tests, and other biological measures to see how rapid treatments like Esketamine and electroconvulsive therapy (ECT) change the brain. The goal is to find ea…

This study looks at how certain brain circuits cause strange sensory feelings in people with Obsessive-Compulsive Disorder (OCD). It will test if a non-invasive brain stimulation technique called rTMS can reduce these symptoms. The study involves 120 adults with OCD and healthy v…