Sahlgrenska University Hospital

Researchers are testing whether a lower dose of the clot-dissolving drug alteplase can treat life-threatening pulmonary embolism as effectively as the standard full dose while causing less severe bleeding. The trial enrolls adults with acute high-risk pulmonary embolism, a condit…

This trial compares two ways of placing a pacemaker lead in people who develop a slow heart rhythm after cardiac surgery. One method uses conventional right ventricular pacing, while the other uses left bundle branch area pacing, which aims to activate the heart more naturally. T…

This trial tests whether a short course of romosozumab followed by denosumab can increase bone density more than the standard treatment zoledronic acid in postmenopausal women with osteoporosis and high fracture risk. Participants receive either the romosozumab-denosumab sequence…

This study tests whether a potassium binder called Sodium Zirconium Cyclosilicate can help heart failure patients take higher, more effective doses of a standard medication (aldosterone receptor antagonist) without dangerous potassium spikes. About 110 adults over 70 with heart f…

This study tests a 20-week program combining a low-calorie diet with exercise in 70 people who have both obesity and COPD. The goal is to see if weight loss can improve how far they can walk in 6 minutes, as well as their lung function, symptoms, and inflammation. If it works, it…

This study looks at whether adding an ultrasound to a CT scan can find more rib cartilage fractures than a CT scan alone. Researchers will follow 100 adults with chest injuries to see if finding these hidden fractures changes treatment, such as whether surgery is needed. Particip…

This study compares two different skin incisions used during surgery to repair a cut tendon in the finger. Seventy patients will be randomly assigned to receive either a standard zig-zag cut or a modified side zig-zag cut. Researchers will measure pain, swelling, and finger movem…

This study compares two surgical treatments for thumb arthritis: a prosthetic joint replacement (arthroplasty) versus removal of a small bone at the thumb base (trapeziectomy). Researchers will enroll 64 adults aged 18-69 with thumb arthritis that hasn't improved with non-surgica…

This observational study will test a behavioral program designed to improve how nurses and anesthesiologists handle IV catheters. Over three years, one hospital will use the program while another continues usual care. Researchers will track complications like phlebitis and infilt…

This study looks at whether placing patients face-down (prone) soon after heart surgery can improve how well the right side of the heart works. The idea is that this position helps open up collapsed parts of the lungs, making it easier for the heart to pump blood. About 80 adults…

This study looks at why some patients develop blood clots after pancreatic surgery that also involves removing a piece of a major vein. Researchers will collect information from over 1,000 patients across many hospitals to see how surgical techniques and blood-thinning medication…

This study looks at whether measuring antithrombin levels in the blood before heart surgery can predict if a patient will respond poorly to heparin, a blood thinner used during surgery. Researchers will collect one extra blood sample from 300 adults undergoing planned heart surge…

This study looks at two surgical techniques for treating unstable chest wall injuries in adults. It compares fixing one fracture per rib versus fixing two fractures per rib to see which leads to better bone healing, lung function, and less pain. One hundred participants will be f…