Pakistan Institute Of Medical Sciences

This trial compares two common ways to close the skin after an elective laparotomy (abdominal surgery): disposable skin staples versus polypropylene sutures. It will include 130 adults aged 15-50 undergoing elective laparotomy, who will be randomly assigned to one of the two clos…

This trial tests whether montelukast, a drug used for asthma, can help infants hospitalized with acute bronchiolitis recover faster. About 60 children aged 4 weeks to 2 years will receive either montelukast or a placebo alongside standard care. Researchers will measure changes in…

This study compares two common surgical methods for treating ingrown toenails: the Winograd technique and the sleeve (gutter) method. Researchers will randomly assign 312 patients to one of the two procedures and track them for 30 days to see which one leads to fewer recurrences …

This study looks at whether measuring the difference in carbon dioxide levels between two types of blood samples can help doctors treat adults with serious injuries better. About 60 ICU patients will be split into two groups: one gets treatment guided by this CO2 gap, the other g…

This study tests whether structured, culturally sensitive counseling can encourage women to continue using their IUD or implant instead of removing it early. 900 women in Pakistan who ask for early removal will be randomly assigned to receive counseling or standard care. The main…

This study compares a new fluoride varnish containing titania nanoparticles (made from moringa leaves) with standard fluoride varnish for reducing dental plaque in people with braces. Twenty patients aged 16-30 will receive one of the two varnishes, and researchers will measure p…

This trial tests whether giving propofol or dexmedetomidine before the end of surgery can prevent emergence agitation, a state of confusion and restlessness that some children experience after waking from sevoflurane anesthesia. The study will enroll 114 children aged 2 to 12 yea…

This trial tests whether watching cartoons or having a parent present during dental treatment better reduces anxiety in children aged 4 to 11. Researchers will measure heart rate and oxygen levels to see which approach is more calming. The goal is to find simple, non-drug ways to…

This study tests whether adding small ridges (like natural ones) to the roof of dentures helps people with no teeth feel more satisfied and improves their quality of life. Sixty adults aged 45 to 80 who need new dentures will try both a standard denture and one with ridges, then …

This study looks at whether a simple neck ultrasound can tell if a septic patient on a ventilator needs more fluids. Doctors will compare this quick method to a standard heart ultrasound. If it works, it could help avoid giving too much or too little fluid, which can be dangerous…

This study tests whether an AI chatbot (custom ChatGPT) giving voice instructions and remote support helps orthodontic patients keep their teeth cleaner than traditional dentist advice and pamphlets. Sixty patients aged 18-30 with new braces will be split into two groups. Researc…