National Institute On Aging (nia)

This early-phase study tested a single dose of bisnorcymserine (BNC) in 75 healthy volunteers aged 55 and older to see how safe it is and how the body processes it. BNC is designed to block a brain chemical that may affect communication between nerve cells, potentially helping wi…

This completed Phase 1 study tested whether giving growth hormone (Norditropin) through a small pump under the skin could improve immune function in healthy men aged 25 to 50. Participants received either growth hormone or a placebo for up to 4 weeks, with frequent blood and urin…

This study tested two drugs that act on the body's endocannabinoid system—nabilone and CP-945,598—to see how they affect insulin production and sensitivity. Forty-five healthy men aged 21 to 55 took part in four visits, each receiving a different drug combination. The goal was to…

This study looked at why many older adults (over 70) have anemia even when doctors can't find a reason. Researchers measured how long red blood cells live in younger and older adults by marking them with a vitamin called Biotin. The goal was to understand if faster red blood cell…

This completed Phase 1 trial studied how two drugs, roflumilast (used for COPD) and sitagliptin (used for diabetes), affect blood sugar and gut hormones in 29 healthy volunteers aged 21-55. Participants received each drug alone, together, or a placebo, then drank a nutritional sh…

This study looked at whether emergency department pharmacists can safely reduce the use of certain brain-active medications in people with dementia or mild cognitive impairment. Researchers worked with 300 participants to see if pharmacists could communicate medication changes to…

This study looks at how aging cells in the skin respond to small injuries. Researchers will take small skin samples from healthy adults aged 20-39 or 70+ to see if older people have more senescent (non-replicating) cells around wounds. The goal is to better understand aging and a…

This study looked at whether a special drink called ketone ester can improve brain energy use and thinking skills in healthy adults aged 55 and older who have metabolic syndrome. Participants took the drink or a placebo for 28 days and had brain scans and memory tests. The goal w…