National Institute Of Environmental Health Sciences (niehs)

This study tests whether omega-3 fatty acid supplements from fish oil can reduce disease activity in adults with dermatomyositis, a rare autoimmune condition causing muscle weakness and skin rashes. About 300 participants will take either fish oil capsules or a placebo for 6 mont…

This study tests an oral drug called H01 (hymecromone) in 37 adults with interstitial lung disease, a condition that causes lung scarring and often leads to death within 3-5 years. Participants take the drug twice daily for 12 weeks. The goal is to see if H01 can lower a marker o…

This study aims to learn more about myositis, a group of diseases that cause muscle inflammation and damage. Researchers will observe up to 1,200 adults and children with myositis, along with healthy volunteers, to track symptoms, immune system changes, and related health issues.…

This study aims to understand how the COVID-19 pandemic has affected the mental, physical, and social well-being of minority women and their families in North Carolina. Researchers will survey 700 healthy women aged 18 and older from African American, Hispanic, Native American, A…

This study looks at how things in your environment—like pollution, chemicals, food, and sleep—might affect your hormones and reproductive system. Researchers will follow 300 people aged 8 and older who have conditions like infertility, late or early puberty, or irregular periods.…

This study follows healthy girls ages 8-14 and those at risk for PCOS to learn how their periods become regular in the first two years after their first period. Researchers will track hormone levels and cycle patterns to understand normal puberty and spot early signs of hormone p…

This study is looking at whether overweight girls start puberty earlier than girls of normal weight. Researchers will use breast ultrasound and other tests to tell the difference between breast tissue and fatty tissue. The study will enroll 150 healthy girls ages 8-14 who have so…

This study looks at whether certain environmental exposures—like infections, stress, or sun exposure—are more common in people with anti-synthetase syndrome (a type of myositis with lung involvement) compared to other myositis patients and healthy volunteers. Researchers will col…

This study aims to find genetic causes of inherited reproductive disorders, such as early or delayed puberty and infertility. Researchers will collect blood samples, medical histories, and smell tests from 850 participants with these conditions and their family members. No treatm…

This study follows 400 nonsmoking adults aged 18 to 60 with moderate to severe asthma for up to 5 years. Researchers collect blood, urine, stool, dust, saliva, and lung samples to see how bacteria and other environmental factors affect asthma symptoms and flare-ups. Participants …

This study aims to understand how environmental factors like pollution, diet, and stress contribute to human diseases. Researchers will collect blood, urine, hair, and other samples from 2,000 healthy adults aged 18 and older. Participants may also complete surveys and provide sa…

This study aims to understand how certain immune cells (neutrophils and monocytes) sense signals in the body and what substances they produce, which can lead to inflammation. Healthy adults aged 18-65 who weigh at least 110 pounds can participate by donating blood up to six times…

This study looks at how a person's genes and their environment (like pollution, diet, and lifestyle) work together to cause common diseases such as diabetes, heart disease, and asthma. Researchers are collecting health questionnaires and genetic data from 25,000 adults to build a…

This study looks at how the immune system's first response (innate immunity) reacts to certain environmental triggers. Researchers want to understand if these reactions are linked to long-term illnesses like asthma, heart disease, and cancer. Healthy volunteers aged 18 to 45 will…