National Institute Of Arthritis And Musculoskeletal And Skin Diseases (niams)

This study is testing if a drug called anifrolumab can improve blood vessel health and reduce inflammation in people with lupus (SLE). Lupus patients have a higher risk of heart disease, and no current medications effectively lower this risk. About 45 participants will receive ei…

This study aims to learn more about inflammatory muscle diseases by collecting information and samples from patients. Researchers will enroll 500 people, including those with suspected or confirmed disease and healthy volunteers. The goal is to understand the causes, progression,…

This National Institutes of Health study aims to learn how systemic lupus erythematosus (SLE) develops, changes over time, and what genetic factors make someone susceptible. It will observe and collect data from up to 2,000 patients (age 3+) with known or suspected lupus and thei…

This study aims to understand why rheumatic diseases, like arthritis, often affect minority communities more severely. It will observe 7,500 adults with known or suspected rheumatic conditions to gather information about their health. Participants will receive standard medical ca…

This study aims to learn more about the causes and long-term course of rare inflammatory diseases like systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD). Researchers will follow up to 2000 children and adults with these conditions over time, col…

This study aims to understand what causes various skin diseases by collecting biological samples from participants. Researchers will gather skin, blood, saliva, and other samples from people with skin conditions, their family members, and healthy volunteers. The collected samples…

This study aims to understand how common eczema treatments, including antibiotics and bleach baths, change the community of bacteria living on the skin. Researchers will observe 130 healthy volunteers and people with moderate-to-severe eczema over one year, collecting skin sample…

This study aims to learn more about rare, lifelong inflammatory diseases like CANDLE, SAVI, and juvenile dermatomyositis. Researchers will observe 5,000 patients and some healthy volunteers over time, collecting medical history, blood samples, and scans. The goal is to understand…

This study aims to learn what happens to people with the rare bone disease melorheostosis over time and what causes it. Researchers will follow 350 adults with the condition, performing exams, scans, and genetic tests every few years to track how the disease changes. The goal is …

This study aims to learn more about a group of rare diseases called vasculitis, which cause damaging inflammation in blood vessels. Researchers will follow up to 4,000 people, including patients and healthy volunteers, over many years to track symptoms, collect blood and tissue s…

This study aims to understand why some people with spondyloarthritis (a type of inflammatory arthritis causing back and joint pain) develop more severe disease, while others do not. Researchers will observe up to 2,000 patients and some of their healthy relatives over time, using…