National Institute Of Arthritis And Musculoskeletal And Skin Diseases (niams)

This study tests whether anifrolumab, a drug already used for lupus, can improve blood vessel function and reduce inflammation in the arteries of people with lupus. About 45 adults with lupus will receive either the drug or a placebo over 8 months. The goal is to see if this trea…

This study looks at whether a drug called GnRHa can help preserve ovarian function in women under 40 with lupus who are treated with cyclophosphamide, a chemotherapy that can cause infertility. Researchers will survey 100 women about their menstrual history and review medical rec…

This study aims to learn more about autoinflammatory diseases, including juvenile dermatomyositis, by observing up to 5,000 patients and healthy volunteers over time. Researchers will collect medical history, blood samples, and imaging to understand disease causes and find better…

This study follows 350 adults with melorheostosis, a rare disease that causes bone thickening, pain, and joint issues. Researchers aim to track how the disease changes over time and identify genetic causes. Participants undergo exams, imaging, and lab tests every two years, with …

This study aims to understand the natural history, genetics, and causes of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD). Researchers will follow up to 2,000 people with these conditions over time, collecting medical history, blood samples, …

This study follows up to 4,000 people with or at risk for vasculitis—a group of diseases that cause blood vessel inflammation—to learn how the condition develops and changes over time. Participants provide blood, urine, and imaging samples, and some have regular check-ups every 3…

This study collects biological samples like blood, skin, and saliva from people with skin diseases, their family members, and healthy volunteers. The goal is to learn what causes different skin conditions and find better ways to treat them. Participants may also answer a survey a…

This study aims to learn more about how lupus (SLE) starts and progresses by observing patients and their relatives over time. Researchers will collect medical histories, blood and urine samples, and genetic material to identify factors that influence the disease. Up to 2000 part…

This study aims to understand how spondyloarthritis (a group of bone and joint disorders causing pain and stiffness) progresses over time. Researchers will observe 2000 participants, including patients and their healthy relatives, using physical exams, blood tests, and imaging li…

This study aims to collect medical information and biological samples (like blood, muscle, and skin) from 500 people aged 12 and older who have or may have inflammatory muscle disease, as well as healthy volunteers. The goal is to better understand what causes these diseases, how…

This study looks at how treatments for eczema (atopic dermatitis) change the types and amounts of bacteria on the skin. Researchers will compare skin samples from people with eczema and healthy volunteers over one year. The goal is to understand how treatments affect the skin's m…

This study aims to learn more about the causes of rheumatic diseases, such as arthritis, and why they often affect minority groups more severely. Researchers will observe up to 7,500 adults with known or suspected rheumatic disease, providing standard medical care and tests. No e…