Montefiore Medical Center

This early-phase trial tests a new drug called FHD-286 combined with two standard chemotherapy drugs (decitabine and venetoclax) in people with acute myeloid leukemia (AML) that is either high-risk or has returned after one prior treatment. The main goal is to find the safest dos…

This study tests a harm reduction strategy for 400 people with HIV who smoke cigarettes. Instead of focusing only on quitting, the program helps participants cut back on smoking, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to reduce the he…

This study compares two methods of helping patients breathe during a cardiac arrest in the hospital: a supraglottic airway (a tube placed in the throat) versus endotracheal intubation (a tube placed into the windpipe). The goal is to see which approach leads to more days alive an…

This study compares three different materials (hard palate tissue, ear cartilage, and a special pig skin product) used as spacer grafts to repair droopy lower eyelids. Researchers will measure eyelid height and check for complications in 100 adults who already had this surgery. T…

This study tests if starting buprenorphine at a low dose is safe and works well for people with opioid use disorder. Researchers will enroll 70 adults to see if patients are willing to join and follow the low-dose plan. The goal is to make treatment easier to begin in primary car…

This study tests whether two immunotherapy drugs (cemiplimab and fianlimab) given before radiation can shrink tumors in people with locally advanced non-small cell lung cancer (NSCLC) who have not had prior treatment. About 76 participants will receive three cycles of the drug co…

This study tests a new, lower-dose weekly schedule of two approved drugs (decitabine and venetoclax) for people with bone marrow cancers like MDS, AML, and CMML. The goal is to see if this gentler approach can control the disease while causing fewer treatment delays or interrupti…

This early-phase study tests a drug called venetoclax combined with standard chemotherapy for adults newly diagnosed with acute myeloid leukemia (AML) or advanced myelodysplastic syndrome (MDS). The goal is to find the safest dose and see how well the combination works. About 99 …

This study gives 400 adults with diabetes or prediabetes free fresh food boxes and nutrition education twice a month for six months. Researchers will check if this helps lower blood sugar levels and reduce food insecurity. The goal is to see if better access to healthy food can i…

This study tests whether adding a community health worker to a kidney care team helps more patients choose or start home dialysis. About 106 adults with advanced kidney disease will be split into two groups: one gets standard team care, the other also gets a health worker to addr…

This study aims to find the most accurate cortisol levels to diagnose adrenal insufficiency, a condition where the body doesn't make enough cortisol. Researchers will test 90 healthy volunteers and patients with known adrenal insufficiency using a more specific cortisol assay. Th…

This study looks at which pain control method works best after rotator cuff repair surgery. Researchers will compare different combinations of pain medications to see which reduces the need for narcotics like oxycodone. About 130 adults who need shoulder surgery will take part. T…

This study tests whether a newer breathing support mode called NAVA helps infants with bronchiolitis breathe more comfortably and reduces the need for a breathing tube compared to standard support. About 130 children under age 2 in the pediatric ICU will take part. The goal is to…

This study tests a type of talk therapy called Trauma-Focused Psychodynamic Psychotherapy (TFPP) for veterans with PTSD who haven't gotten better with standard treatments. About 75 veterans will be randomly assigned to receive either TFPP or their usual care. The goal is to see i…

This study tests a structured psychological support program for teenagers aged 10-19 who are having surgery for scoliosis. The program is based on cognitive behavioral therapy and aims to reduce anxiety, depression, and pain-related distress before and after the operation. Resear…

This study is testing a new type of MRI called TMEM-MRI to see if it can show how breast cancer might spread. Researchers will scan about 95 women with breast cancer to measure how leaky the tumor's blood vessels are. The goal is to learn if this imaging method can help doctors u…

This study looks at whether eating plant-based or animal-based meals changes erectile function in healthy men who already have normal erections. About 46 men will eat four test meals and have their nighttime erections measured with a special device. The goal is to learn if diet a…

This study is for people with a certain type of advanced breast cancer (ER+/HER2-). It aims to see how three common drugs (abemaciclib, ribociclib, or palbociclib) change body composition—like fat and muscle—over 24 weeks. Researchers will use CT scans and DEXA scans to measure t…

This pilot study looks at 10 people with a new diagnosis of high-grade osteosarcoma in an arm or leg. Researchers want to see if removing the tumor with surgery before starting chemotherapy leads to better movement and quality of life. Patients and surgeons will fill out question…

This study looks at how being told you have an unruptured brain aneurysm (a weak spot on a blood vessel in the brain that hasn't burst) affects your mental health. Researchers will compare two groups of 120 people: those who simply get regular check-ups and those who have a proce…

This study looks at whether a single meal of plant-based meat versus animal meat changes nighttime erections in 30 healthy men. Participants eat one test meal and then sleep with a monitor that measures erection firmness and duration. The goal is to see if the type of meat makes …

This study looks at why some babies who had restricted growth in the womb are more likely to become obese children. Researchers will study immune cells from 400 newborns to see if certain DNA changes affect growth. The goal is to understand the early programming of obesity, not t…

This study looks at how social factors like insurance and medication adherence affect quality of life in Hispanic and Black patients with inflammatory bowel disease (IBD). Researchers will survey 400 adults with IBD to understand these links. The goal is to find ways to improve h…

This study looks at whether cancer patients will regularly use a mobile app called RestoreMe to help with diet, nutrition, and physical activity during their treatment. About 50 patients with various cancers who are receiving radiation therapy will be asked to use the app. The ma…

This study is a global registry that will follow 800 people who receive a new, less invasive heart valve replacement for a leaky tricuspid valve (tricuspid regurgitation). The goal is to learn how safe and effective the procedure is, and to understand complications like the need …