Latin American Cooperative Oncology Group

This Phase 2 trial tests amivantamab, a targeted drug given as a shot under the skin, in adults with advanced penile cancer that has spread or returned after at least one round of platinum-based chemotherapy. The study includes two groups based on HPV status and measures how many…

Penile squamous cell carcinoma is a rare and aggressive cancer with limited options once it progresses after platinum-based chemotherapy. This phase 2 trial tests sacituzumab tirumotecan, an antibody-drug conjugate that targets the TROP-2 protein on cancer cells, in about 37 part…

This phase II trial tests whether sacituzumab tirumotecan (Sac-TMT) can shrink tumors in people with advanced or metastatic squamous cell carcinoma of the vagina or vulva. These cancers are rare, and there is no standard second-line treatment. Sac-TMT is an antibody-drug conjugat…

This study tests whether a machine learning model called PROTEGER can help doctors choose the right cancer treatment for adults aged 65 and older with solid tumors. Researchers will train the model on past patient data, then check its accuracy in a new group of patients across Ch…

This study looks back at the medical records of 350 people in Brazil diagnosed with IDH-mutant diffuse glioma, a type of brain tumor, from 2021 onward. Researchers will collect information on age, race, income, education, and other factors to build a detailed picture of who gets …

This study evaluates whether the G8 screening tool can accurately identify frailty and predict early death in adults aged 70 and older who are newly diagnosed with solid tumors. Researchers will assess 250 participants via phone or video calls, using a comprehensive geriatric ass…

This study examines tumor samples from 320 Latin American women with advanced ovarian, fallopian tube, or peritoneal cancer to describe the presence of certain markers (FRα, HER2, PD-L1, HRD, and BRCA). Researchers will collect medical history and test archived tumor tissue to se…