Latin American Cooperative Oncology Group

This trial tests whether a combination of the immunotherapy drug pembrolizumab, chemotherapy, and radiation can control advanced larynx cancer while preserving the voice box. Adults with stage III or IV larynx cancer who are candidates for organ preservation receive three cycles …

This Phase 2 trial tests a combination of three drugs—amivantamab, lazertinib, and pemetrexed—as a first treatment for people with advanced lung cancer that has a specific EGFR mutation. The study includes 54 participants across Latin America. Researchers want to see if this comb…

This phase 2 trial is testing a combination of two hormone-based drugs—darolutamide and high-dose testosterone—in 51 men with metastatic castration-resistant prostate cancer, a form that no longer responds to standard hormone therapy. The approach, called extreme bipolar androgen…

This study looks at medical records from 584 men in Brazil with castration-resistant metastatic prostate cancer, a form of the disease that no longer responds to hormone therapy. Researchers aim to describe how long these patients survive and to identify their individual characte…

This study looks back at the medical records of 150 adults in Brazil diagnosed with adrenocortical carcinoma, a rare cancer of the adrenal glands. Researchers will collect details on age, gender, location, tumor stage, hormone activity, and treatments received since the year 2000…

This study looks back at the medical records of 88 adults with neuroendocrine tumors that have spread or cannot be removed. Researchers will examine how different patient characteristics and treatments relate to overall survival and other outcomes. The goal is to identify factors…

This study builds a global registry of adults with anal squamous cell carcinoma, both with and without HIV infection. Researchers will collect real-world data on treatments, lab results, and outcomes to compare how the disease progresses in each group. The goal is to identify fac…

This study looks back at the records of 461 women in Brazil who received a short, high-dose radiation schedule after breast cancer surgery. The schedule, called extreme hypofractionation, delivers 5 doses of 5.2 Gy instead of many smaller doses. Researchers want to see how well t…

This observational study will examine the molecular and epidemiological characteristics of endometrial cancer in Brazil, focusing on women diagnosed between 2016 and 2019. Researchers will analyze tumor samples for genetic mutations and biomarkers, and collect data on demographic…

This study looked at 218 patients with advanced bladder cancer in Latin America. Researchers collected information on patient backgrounds, treatments, and survival. The goal was to better understand the disease in this region, not to test a new treatment.