Karyopharm Therapeutics Inc

This program offers the investigational drug selinexor to people with multiple myeloma, lymphoma, sarcoma, or other cancers who have run out of approved treatments and cannot join a clinical trial. It is not a cure but aims to control the disease. Patients must get approval from …

This study tests a drug called selinexor in about 58 adults with myelofibrosis (a bone marrow disorder) who have mild to moderate low platelet counts and have not taken JAK inhibitors before. The main goal is to see if selinexor can shrink the spleen by at least 35% after 24 week…

This study tests a drug called selinexor as a long-term maintenance treatment for people with a specific type of advanced or recurrent endometrial cancer (p53 wild-type). Participants must have already responded well to at least 12 weeks of platinum-based chemotherapy. The goal i…

This study tests a drug called selinexor combined with low-dose dexamethasone, with or without bortezomib, in people with multiple myeloma that has stopped responding to many other treatments. The goal is to see if these combinations can shrink tumors and control the disease. Abo…