New hope for myelofibrosis patients: selinexor trial targets enlarged spleens
NCT ID NCT04562870
First seen Nov 01, 2025 · Last updated May 20, 2026 · Updated 30 times
Summary
This study tests a drug called selinexor in people with myelofibrosis, a rare bone marrow disorder, whose disease has not improved enough after at least 6 months of standard JAK inhibitor therapy. About 112 participants will be randomly assigned to receive either selinexor or another treatment chosen by their doctor. The main goal is to see if selinexor can shrink an enlarged spleen by at least 35%, which is a key measure of disease control.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Affiliated Hospital of Nantong University
Nantong, Jiangsu, 226001, China
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Asst Settelaghi, Ospedale Di Circolo E Fondazione Macchi
Varese, 21100, Italy
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Azienda Unita Sanitaria Locale Latina - Ospedale Santa Maria Goretti
Latina, 4100, Italy
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Centre Hospitalier Universitaire d'Angers (CHU Angers)
Angers, 49933, France
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Hospital Universitario 12 de Octubre
Madrid, Madrid, 28041, Spain
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Illinois Cancer Specialist
Niles, Illinois, 60714, United States
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Institut de Cancéro-Hématologie
Brest, Brittany Region, 29609, France
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Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS
Meldola, Forlì-Cesena, 47014, Italy
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Peking Union Medical College Hospital
Beijing, Beijing Municipality, 100730, China
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Pratia Onkologia Katowice
Katowice, 40-519, Poland
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Rocky Mountain Cancer Centers, LLP
Aurora, Colorado, 80012, United States
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Sir Run Run Shaw Hospital - Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310016, China
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Suzhou University -The First Affiliated Hospital
Suzhou, Jiangsu, 215007, China
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Texas Oncology - Northeast Texas
Tyler, Texas, 75702, United States
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The First Hospital of Jilin University
Changchun, Jilin, 130021, China
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The Oncology Institute of Hope and Innovation
Pasadena, California, 91105, United States
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The Second Affiliated Hospital of Soochow University
Suzhou, Jiangsu, 215004, China
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Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, 430022, China
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University General Hospital "ATTIKON"
Athens, Attica, 12462, Greece
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University of Perugia Department of Medicine Hematology Section
Perugia, 6132, Italy
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Università degli Studi di Firenze - Azienda Ospedaliero - Universitaria Careggi - Dipartimento di medicina sperimentale e clinica
Florence, 50134, Italy
Conditions
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