Karolinska University Hospital

This study compares a newer targeted drug, trastuzumab deruxtecan (T-DXd), with standard chemotherapy and targeted therapy given before surgery for HER2-positive breast cancer. About 370 adults with large or lymph node-positive tumors will receive either T-DXd or standard treatme…

This study compares robotic-assisted surgery to traditional open surgery for people with gallbladder cancer who need a radical cholecystectomy. About 94 participants from multiple countries will be randomly assigned to one of the two procedures. The main goal is to see which appr…

This early-phase study tests a new radioactive drug, [177Lu]Lu-AKIR001, in 15 adults with advanced solid tumors (like thyroid, head and neck, cervical, vulvar, or lung cancer) that have stopped responding to standard treatments. The main goal is to check the drug's safety and sid…

This observational study looks at over 50,000 critically ill patients with acute kidney injury to see if starting dialysis earlier improves survival. Researchers will analyze data from intensive care units in Sweden, comparing patients who received early versus late dialysis. The…

This study follows 1,000 adults who have long-term bladder or bowel problems from past cancer radiation and are receiving hyperbaric oxygen therapy (HBOT). Researchers want to learn which patients improve most and when treatment works best. The goal is to better understand how to…

This study looks at why some people who have had a stem cell transplant feel very tired and have trouble thinking clearly. Researchers will use brain scans and spinal fluid tests to see if inflammation in the brain is the cause. The goal is to better understand these problems, no…