Karolinska Institutet

This study aims to see if just one dose of the HPV vaccine is enough to protect young adult women from infection by cancer-causing HPV types. It involves up to 150,000 women in Sweden who are part of a national program to eliminate cervical cancer. The goal is to gather evidence …

This study is testing whether an online program called 'Tiny Heroes' is a practical and helpful tool for parents. The program teaches parents strategies based on cognitive behavioral therapy (CBT) to help reduce anxiety in their young children (ages 3-6). Researchers are working …

This study compares two surgical procedures for people with advanced wrist arthritis from old injuries. Researchers want to see if a newer surgery (lunate-capitate fusion) works as well as the standard surgery (four-corner fusion) at preserving grip strength and wrist function. T…

This study is testing whether adding practical home decluttering visits to standard group therapy is more effective for treating hoarding disorder. It involves 90 adults in Sweden who will first complete therapy and then be assigned to either receive home visits or wait. The goal…

This study compares two different online therapy programs for people with generalized anxiety disorder. 400 participants will try either a program focused on managing uncertainty or one focused on changing thinking patterns about worry. Both programs involve 10 weeks of guided se…

This pilot study aims to see if it's practical to run a larger trial comparing two types of cognitive-behavioral therapy (CBT) for anxiety. It tests a single, unified therapy approach against several specific therapies tailored to different anxiety disorders. The study enrolled 7…

This early-stage trial is testing whether stem cells from a donor, given to infants before or after birth, are safe and can help treat severe osteogenesis imperfecta (brittle bone disease). The study involves up to 18 infants and compares them to children who did not receive this…

This study compares two surgeries for a painful jaw joint condition where the disc slips out of place. Researchers are looking back at the records of 65 patients who had either a less invasive arthroscopic procedure or a more traditional open surgery. They aim to see which method…

This study is following 7,500 men for many years to compare different ways of screening for prostate cancer. It aims to find out which combination of blood tests, special biomarker tests, and MRI scans is most effective at finding serious cancers early and reducing deaths. The re…

This study aimed to test two new methods for detecting kidney injury much sooner after heart surgery. Researchers planned to use a special kidney ultrasound and a quick urine test within hours after surgery, comparing them to standard blood tests. The goal was to create a better …

This study tests whether offering online birth control counseling at pharmacies helps women choose effective, ongoing contraception after they buy emergency contraception. About 600 women in Stockholm who purchase emergency contraception will either receive this counseling or sta…

This study is testing a short, universal parent support program called 'Little ACF' to see if it can help parents of 1-2 year olds. 670 families are randomly assigned to either attend four group meetings with other parents or receive standard child health care plus a lecture. Res…

This study tests whether a short, personalized online message can encourage more people with risky alcohol use to seek help from their local social services. Researchers are working with 200 anonymous users of a Swedish alcohol-help website. They will compare whether receiving sp…

This study is testing whether a 10-week online health promotion program can help adults living long-term with spinal cord injury develop healthier habits and improve their overall well-being. Researchers will compare about 30 people who take the weekly video course (covering topi…

This study is testing a fun, play-based training program to help young children (ages 2-5) with cerebral palsy move more easily and be more active. Kids will participate in weekly group sessions for 12 weeks, using special three-wheeled running frames and other aids during games …

This study is testing whether a 10-week online parenting course can help reduce disruptive behaviors in young children aged 2-7. Twenty parents will receive guided online therapy sessions to learn better interaction skills with their children. The main goal is to see if this inte…

This research project aims to understand how specific large-scale changes in a person's DNA can cause rare congenital brain disorders. The study will analyze genetic data from up to 10,000 individuals with suspected rare diseases or chromosome abnormalities. Researchers will use …

This study looks back at the medical records of 1,500 critically ill patients to understand if having a 'do not resuscitate' order is connected to a higher chance of dying. Researchers will check if this link holds true even after considering factors like the patient's age, sex, …

This study is testing a practical method to help organizations improve their workplace health management by focusing on positive factors that support employee well-being, rather than just identifying problems. Municipal work units with more than three employees will use a goal-se…

This project aimed to create a web-based decision aid to help people in Sweden make more informed choices about participating in cancer screening programs. It focused on breast, cervical, and bowel cancer screening. The tool was designed to provide clear information and help user…

This study aims to understand why people with Long COVID often experience severe fatigue and feel much worse after exercise. Researchers are comparing 62 people with Long COVID to healthy volunteers, having them try different types of exercise while closely monitoring their bodie…