Massive 10,000-Person gene hunt for rare brain disease clues

This research project aims to understand how specific large-scale changes in a person's DNA can cause rare congenital brain disorders. The study will analyze genetic data from up to 10,000 individuals with suspected rare diseases or chromosome abnormalities. Researchers will use advanced lab techniques, including studying cells and zebrafish, to map how these DNA changes disrupt normal development and lead to disease, with the goal of improving future genetic testing and treatment strategies.