Italian Sarcoma Group

This study tests two chemotherapy drugs, lurbinectedin and irinotecan, in 20 patients aged 15 and older with advanced DSRCT that cannot be surgically removed. The goal is to shrink or control the tumor and track side effects. An optional genetic analysis will help researchers und…

This study tests two chemotherapy drugs, trabectedin and gemcitabine, in 100 people with advanced leiomyosarcoma that has spread or cannot be removed. Participants have already tried one prior treatment. The goal is to see which drug better delays tumor growth. The study also inc…

This study compares two standard treatments—surgery and radiation therapy—for people with a rare tumor at the base of the spine called sacral chordoma. About 100 adults with newly diagnosed, localized disease will be followed to see which approach better prevents the tumor from c…

This study tests the drug trabectedin in 16 people aged 16 and older with advanced mesenchymal chondrosarcoma, a rare bone cancer that has spread or cannot be removed. Participants must have already tried at least one chemotherapy. The goal is to see if trabectedin can shrink tum…

This study is observing 100 people diagnosed with Ewing sarcoma of the bone to collect information about their disease, treatments, and outcomes. It does not test any new treatments. The goal is to better understand the disease and how current treatments affect survival and side …

This study is collecting information from 100 people with endometrial stromal tumors, a rare type of uterine cancer. Researchers are tracking how the disease progresses over time, how it is diagnosed, and what treatments patients receive. The goal is to better understand the dise…

This study follows 250 people diagnosed with localized angiosarcoma, a rare cancer of the blood vessels. Researchers will collect information on patient characteristics, tumor features, and treatments used in everyday practice. The goal is to learn more about the disease and impr…

This study is watching and recording what happens to 100 people with epithelioid sarcoma, a rare type of cancer. Researchers want to learn which treatments (like chemotherapy or radiation) are used and how patients respond. The goal is to gather information to help doctors make b…

This study looks back at 300 people diagnosed with breast sarcoma between 2000 and 2020. Researchers will review medical records to understand symptoms, treatments, and how the disease progressed. The goal is to find patterns that can help doctors manage and treat this rare cance…

This study is observing 120 patients with localized osteosarcoma (a type of bone cancer) to collect information on their treatments and results. Researchers will track how long patients stay free of cancer and their overall survival. The goal is to learn more about current treatm…