Instituto Nacional De Cancerologia De Mexico

This phase 3 trial tests whether adding metformin, a standard diabetes drug, to standard targeted therapy (tyrosine kinase inhibitors) can help people with advanced EGFR-mutant non-small cell lung cancer live longer without their cancer growing. About 312 participants will receiv…

This study tests whether taking inhaled budesonide (a steroid) twice daily during radiation therapy can reduce the severity of radiation pneumonitis—a common and serious lung inflammation—in people with non-small cell lung cancer. About 72 patients will be randomly assigned to re…

This phase III trial tests whether adding nitroglycerin patches to standard radiation therapy helps shrink brain tumors better than radiation alone in people with a specific type of lung cancer (EGFR-mutant non-small cell lung cancer). 74 participants will receive either radiatio…

This study is testing the drug alectinib in 45 Mexican patients with advanced ALK-positive non-small cell lung cancer. In the first phase, patients receive increasing doses every 21 days to measure drug levels and safety. In the second phase, the chosen dose is given to see how w…

This study will give yearly low-dose CT scans to 1,000 people in Mexico who are at high risk for lung cancer—including heavy smokers, former smokers, and those exposed to wood smoke. The goal is to see if regular screening can find lung cancer at an earlier, more treatable stage.…

This study tests whether adding glutamine and a probiotic (Lactobacillus reuteri) to a bland diet can prevent diarrhea caused by targeted therapy (TKIs) in people with advanced EGFR-mutant non-small cell lung cancer. About 28 participants will either receive the supplemented diet…

This study tests whether a 12-session pulmonary rehabilitation program—including breathing exercises, resistance training, and treadmill walking—can help patients with advanced non-small-cell lung cancer maintain muscle mass, improve lung function, and reduce inflammation. The go…

This study looks at how a person's fat-free mass (like muscle) affects the dose and side effects of the chemotherapy drug carboplatin in patients with advanced non-small cell lung cancer. Researchers will track 132 patients to see if body composition is linked to toxicity. The go…

Researchers in Mexico are developing a questionnaire to measure how well lung cancer patients follow their respiratory rehabilitation program. The study will enroll 281 adults with lung cancer who are currently in rehab. Participants will fill out a 56-item scale, and the researc…