Institute Of Cancer Research, United Kingdom

This study looks at whether men with a certain type of advanced prostate cancer (castration-resistant) who have inherited DNA repair gene mutations respond better to the chemotherapy drug carboplatin. Researchers will first screen participants for these genetic changes, then trea…

This Phase I trial tests a combination of two oral drugs, defactinib and VS-6766, in people with advanced solid tumors such as non-small cell lung cancer, low-grade serous ovarian cancer, and pancreatic cancer. The study aims to find the safest dose and evaluate how well the drug…

This early-stage study tests whether adding tepotinib (a targeted drug) to pembrolizumab (an immunotherapy) can help shrink tumors in people with advanced non-small cell lung cancer. It includes patients whose cancers have or lack a specific MET gene change. The goal is to see if…

This phase 2 trial tests a new drug (ceralasertib) alone or combined with either olaparib or durvalumab in 174 people whose gynaecological cancer has returned. The study groups patients by their cancer type and whether they have a change in the ARID1A gene. The goal is to see if …

This phase 3 trial tests whether adding the drug abemaciclib to standard hormone therapy can lower the chance of breast cancer returning in postmenopausal women with a high-risk type. About 123 participants will receive either hormone therapy alone or with abemaciclib for up to 2…

This study collects genetic information from nearly 24,000 men with prostate cancer to find inherited genes that increase risk. It focuses on younger men and those with a family history, where genetics likely play a bigger role. The goal is to understand why some men develop pros…

This study looks at whether yearly PSA tests can find prostate cancer early in men who have inherited certain gene mutations (BRCA1, BRCA2, or mismatch repair genes) that raise their risk. About 3,500 men aged 40-69, both with and without these mutations, will be screened and com…

This study looks at blood samples from 25 cancer patients receiving radiation therapy. Researchers want to find specific genes that show how each person's body responds to radiation. The goal is to better understand individual reactions and possibly personalize radiation treatmen…

This study looks at whether a simple genetic test can identify men who are more likely to have prostate cancer, so screening can be focused on them. About 300 Caucasian men aged 55 to 69 will provide a DNA sample and, if their genetic risk score is high, they will be offered a pr…