Institute Of Cancer Research, United Kingdom

This trial tests two experimental drugs, avutometinib and defactinib, alone or with chemotherapy, in adults with aggressive brain tumors like glioblastoma. The goal is to see if the combination is safe and can shrink tumors or slow their growth. About 182 participants will join t…

This study tests whether adding an experimental drug (SX-682) to a standard hormone therapy (apalutamide) can help men with a hard-to-treat type of advanced prostate cancer. About 78 men will take part to find the safest dose and see if the combination shrinks tumors or lowers PS…