Helsinki University Central Hospital

This study compared two surgical techniques for treating concha bullosa, a condition where the middle nasal turbinate is enlarged with air. Researchers followed 62 patients with chronic sinusitis who underwent sinus surgery, randomly assigning them to either have the enlarged tis…

This study tested whether counseling from a pediatrician and social worker could help families keep follow-up dental appointments after their young children had cavities treated under general anesthesia. Researchers worked with 89 families in Finland to see if this support would …

This study looked at how grapefruit juice and another medication affect how the body processes esketamine, a drug used for depression and pain. Researchers gave 12 healthy volunteers esketamine either as a nasal spray or by mouth, along with either grapefruit juice, the other med…

This study aims to understand if two widely used medications—carvedilol (for heart conditions) and diclofenac (an anti-inflammatory painkiller)—affect how the body breaks down other drugs. Researchers gave 12 healthy volunteers a combination of several low-dose 'probe' drugs, alo…

Primary objective: to investigate the efficacy of Mepolizumab 100 milligram (mg) every month compared to placebo in reducing validated Sinonasal Outcome Test -22 score and on reducing endoscopic Nasal Polyp Score. The participants have a triad of chronic rhinosinusitis with nasa…