Grapefruit juice may change how esketamine works in the body
NCT ID NCT06726382
First seen Mar 11, 2026 · Last updated May 21, 2026 · Updated 14 times
Summary
This study looked at how grapefruit juice and a drug called cobicistat affect the amount of esketamine in the blood. Esketamine is used for depression and pain relief. Twelve healthy adults took esketamine as a nasal spray or by mouth, with either grapefruit juice, cobicistat, or water. Researchers measured drug levels over 24 hours to understand these interactions.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Department of Clinical Pharmacology
Helsinki, Finland
Conditions
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