Guy's And St Thomas' Nhs Foundation Trust

This small study is testing whether adding a special anti-inflammatory mouthwash to a deep cleaning treatment works better for advanced gum disease. Twenty participants with severe gum disease will receive the deep cleaning and be randomly assigned to use either the test mouthwas…

This study aims to see if a new digital weight management program can improve health services and outcomes for people living with obesity. It will enroll 580 adults already referred to a specialist NHS weight management service. Researchers will compare the digital program to sta…

This study compares two medical devices designed to help deliver a baby when its head becomes stuck during an emergency C-section performed late in labor. Researchers will observe 80 women needing this procedure to see which device—the established Fetal Pillow or the newer Tydema…

This study is checking if it's possible to run a larger future trial. That trial would test whether a natural protein from cow's milk, called lactoferrin, can be used as a vaginal treatment for common infections like bacterial vaginosis (BV) and thrush. Researchers will recruit 1…

This study is testing a small, quick device called Seismofit to measure fitness in patients undergoing treatment for esophageal cancer. The goal is to see if this simple test, done while lying down, can predict complications and hospital stay length better than the current, longe…

This study is testing a new urine test to spot early signs of kidney transplant problems. Researchers will check if a protein called DKK3 in urine can warn of transplant issues earlier than current blood tests. They will follow 258 kidney transplant patients for a year, collectin…

This study aims to understand why atrial fibrillation (an irregular heartbeat) is more common and harder to treat in people with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle is abnormally thick. Researchers will study 40 adults with both conditions who ar…

This study aims to understand the experiences of pregnant and postnatal women who have two or more long-term health conditions, such as diabetes or heart disease, and the midwives who care for them. Researchers will conduct interviews with these women and healthcare staff to lear…

This study aims to understand why ethnic minority groups in England use genetic testing services less often than other groups. Researchers will interview 100 people from ethnic minority backgrounds, community workers, and healthcare professionals about their experiences with gene…

This study aims to understand how two common blood-thinning medications, aspirin and clopidogrel, affect inflammation in the arteries of people with silent atherosclerosis. Researchers will measure specific blood cell clusters linked to artery disease in 60 participants who have …

This study is testing a new, more detailed health check designed specifically for older adults being evaluated for a kidney transplant. Researchers want to see if adding this 45-60 minute check to the standard assessment is practical and acceptable for patients and doctors. The s…