Georgetown University

This early-stage trial is testing the safety and initial effectiveness of a new two-drug combination (NEROFE plus doxorubicin) for patients with advanced solid tumors that have specific genetic markers (KRAS mutation and ST2 protein). The main goal is to find the safest dose and …

This early-stage study is testing if a drug called azeliragon can protect the heart and brain from damage caused by chemotherapy in women with early-stage breast cancer. Researchers will give azeliragon alongside standard chemotherapy to about 48 participants to see if it's safe …

This study is testing whether a drug called sacituzumab govitecan can help control advanced thymoma and thymic carcinoma in adults whose cancer has continued to grow despite previous treatments. Participants will receive the drug through an IV every three weeks until their cancer…

This study aims to find the most effective way to help people quit smoking when they come in for lung cancer screening. Researchers will compare two different phone-based support programs—one run by a state quitline and one run directly by the health system—for 1,188 current smok…

This study is testing whether adding two immunotherapy drugs (durvalumab and tremelimumab) to standard chemotherapy is safe and effective for treating advanced non-small cell lung cancer in people who also have HIV. It will enroll 18 adults with stage IV lung cancer who are on st…

This study is testing whether combining two existing drugs, pembrolizumab and lenvatinib, can help control advanced cervical cancer that has worsened after standard treatment. It will involve about 35 women to see if the combination shrinks tumors and for how long. The goal is to…

This study is testing whether a drug called CPX-351 can help keep acute myeloid leukemia (AML) in remission for patients who have already achieved remission but are not eligible for a bone marrow transplant. The goal is to see if giving this drug as ongoing 'maintenance' therapy …

This study is testing a gentler radiation treatment for people with HPV-positive throat cancer who have already had surgery. Researchers want to see if using a lower radiation dose and targeting only the neck (instead of the original tumor site too) works as well as the standard,…

This study is testing whether a 6-month telehealth program using smartphones can help cancer survivors prevent painful mouth sores and gum disease, improve their quality of life, and reduce body-wide inflammation. It will compare this program to usual care in 100 cancer survivors…

This study is testing a specific treatment plan for people with a hard-to-treat form of advanced lung cancer that has spread to distant lymph nodes. The goal is to see if giving a combination of chemotherapy and immunotherapy drugs *before* surgery can shrink the cancer enough to…

This study aims to find the best ways to help people in Malawi continue taking HIV prevention medication. It will test a package of support strategies at clinics and community centers, focusing on helping people stay on either daily pills or a newer long-acting injection. The goa…

This study is testing whether a special website can help adults who have had thyroid cancer feel better after radioactive iodine treatment. Researchers want to see if the website, which offers education and symptom management tips, improves patients' overall well-being compared t…

This study is testing whether an online program can help Black men who have survived prostate cancer and are struggling with insomnia. It will compare a structured internet therapy program to a simple educational website. The main goal is to see if the online approach is practica…

This study is testing a decision support tool to help high-risk Black and Latina women make informed choices about whether to add a breast MRI to their annual mammogram. Researchers will compare the tool against standard care in 80 participants. The goal is to see if the tool imp…

This study is testing whether a special website helps people recently diagnosed with a moderate-risk thyroid cancer make a more informed decision about radioactive iodine treatment. About 408 participants will be randomly assigned to either use this interactive decision aid websi…