Georgetown University

This phase 2 study tests whether adding tiragolumab to the standard combination of atezolizumab and bevacizumab can shrink tumors in people with advanced non-squamous lung cancer that has worsened after prior treatment. The trial enrolls 29 adults whose tumors have certain geneti…

This Phase 2 study is testing a combination of three drugs—nanoliposomal irinotecan, fluorouracil, and leucovorin—in 48 adults with advanced biliary tract cancer that has progressed after initial chemotherapy. The main goal is to see if the treatment can stop the cancer from grow…

This study tests a combination of two drugs, venetoclax and rituximab, in people whose chronic lymphocytic leukemia (CLL) has come back or stopped responding to previous treatments. The goal is to see how well the combo works at shrinking or controlling the cancer. About 25 adult…

This study tests a drug called MGC018 in people with extensive-stage small-cell lung cancer that has come back or not responded to treatment. The main goal is to see if the drug can shrink tumors in at least 25% of participants. Patients receive the drug through an IV every 28 da…

This study tests a combination of two drugs, BXCL701 and pembrolizumab, in 22 people with advanced pancreatic cancer that has spread. The goal is to see if this treatment can stop the cancer from growing for at least 18 weeks. Participants must have already tried one prior treatm…

This study tests a combination of three drugs (nivolumab, ipilimumab, and cabozantinib) in 14 adults with advanced melanoma that cannot be surgically removed. Participants receive the triple therapy for 12 weeks, then switch to two drugs for up to 2 years. The goal is to see how …

This early-phase trial tests a two-step treatment for advanced breast cancer that cannot be cured with surgery or radiation. First, patients receive a drug called talazoparib alone, then both talazoparib and avelumab together. The main goal is to check safety and side effects, wh…

This study tests whether personalized computer games can help people with Rett syndrome use their arms more purposefully and reduce repetitive hand movements. Fourteen participants will play games that reward them for separating their hands and reaching for targets. The training …

This study tests whether a home-based walking program can improve blood sugar, cholesterol, and body measurements in people living with HIV who also have metabolic syndrome. Fifty participants will gradually increase their walking over six months. The main goal is to see if the p…

This study looks at whether a web-based educational program can help relatives of people with BRCA1 or BRCA2 mutations understand their genetic testing options. About 240 adults who are close relatives of someone with a BRCA mutation will take part. Participants will either use t…