Georgetown University

This trial tests a two-step treatment for people with advanced breast cancer that cannot be cured by surgery or radiation. First, patients receive a drug called talazoparib alone, then they get talazoparib combined with avelumab. The main goal is to check safety and side effects,…

This study tests a drug called MGC018 in people with a hard-to-treat type of lung cancer (extensive-stage small-cell lung cancer) that has come back or not responded to prior treatment. The main goal is to see if the drug can shrink tumors in at least 25% of participants. Patient…

This study aimed to test if daratumumab could improve nerve damage (peripheral neuropathy) in people with a blood condition called MGUS. Participants would have received weekly injections for two months, then biweekly for four more months. However, the trial was withdrawn before …

This study tests a combination of three drugs (nivolumab, ipilimumab, and cabozantinib) in people with advanced melanoma that cannot be removed by surgery. The goal is to see if this triple therapy can keep the cancer from growing for at least one year. Participants receive the d…

This study tests a technology-based motor rehabilitation program for 14 people with Rett syndrome. The goal is to help them use their arms more purposefully while reducing repetitive hand movements. Participants play specially designed games that reward keeping hands apart and re…

This study looks at whether a web-based educational program can help relatives of people with BRCA1 or BRCA2 mutations understand their genetic testing options. About 240 adults who have a close family member with a BRCA mutation will be randomly assigned to either the online edu…