Fox Chase Cancer Center

This early-phase study tests whether Adaptive Radiation Therapy (ART) can safely deliver precise radiation to aggressive pancreatic tumors while protecting nearby organs. Sixteen adults with locally advanced, inoperable pancreatic cancer will receive five radiation sessions over …

This early-phase trial tests a type of radiation that adapts to the tumor's shape and location, allowing doctors to give a higher dose to cancer in the abdomen or pelvis while keeping severe side effects under 10%. About 30 adults with metastatic solid tumors (any type) that need…

This study tests whether using a special scan (lymphoscintigraphy) to guide radiation only to the side of the neck with cancer can prevent the cancer from spreading to the other side while reducing dry mouth. About 22 adults with HPV-positive oropharynx cancer that has not spread…

This early-phase trial tests whether adding an experimental drug, CADI-05, to the standard immunotherapy pembrolizumab can help the immune system better attack head and neck cancer before surgery. About 22 adults with locally advanced, surgically removable cancer will receive bot…

This early-phase study tests whether adding an experimental drug called CBL0137 to standard immunotherapy (ipilimumab and nivolumab) is safe and can help shrink advanced melanoma. About 12 adults with stage III or IV melanoma that can be biopsied will take part. The main goal is …

This early-phase trial tests a combination of two targeted drugs, neratinib and fam-trastuzumab deruxtecan (Enhertu), in people with advanced stomach, esophageal, or other gastrointestinal cancers that have stopped responding to standard treatments. The main goal is to find the s…

This study tests a different way of taking the drug cabozantinib to see if it causes fewer side effects while still controlling cancer growth. It includes adults with advanced kidney cancer or neuroendocrine tumors. The goal is to find a dose schedule that patients can tolerate b…

This study tests whether a maintenance dose of the immunotherapy drug pembrolizumab can help keep advanced bladder cancer from progressing after an initial combination treatment. About 97 adults with untreated metastatic urothelial carcinoma will receive the combo therapy for 18 …

This early-phase study tests whether giving extra, MRI-guided radiation after standard chemoradiation is safe for people with rectal cancer. About 37 participants will receive standard treatment plus a personalized boost every two weeks, followed by more chemotherapy. The goal is…

This study tests a new way to give radiation for prostate cancer that adapts to your body shape each day. The goal is to safely give a higher dose to the cancer while protecting nearby organs. About 80 adults with intermediate- or high-risk prostate cancer will receive 5 treatmen…

This study is testing whether a combination of blood and urine DNA tests can detect muscle-invasive bladder cancer that standard scopes might miss before bladder removal surgery. About 92 adults scheduled for cystectomy will provide samples to see if the test accurately predicts …

This study is for Asian American cancer patients and their caregivers. It tests a program of positive activities designed to improve emotional well-being and quality of life. The goal is to reduce the burden patients feel they place on their caregivers. About 186 people will take…

This study tests whether an educational video and workbook can help gynecologic cancer patients bring up sexual health concerns with their doctors. About 200 patients will either receive the program plus a resource booklet, or just the booklet with usual care. Researchers will co…

This study tests whether taking cannabidiol (CBD) capsules can help prevent nerve damage caused by the chemotherapy drug oxaliplatin in people with colorectal cancer. About 30 participants will be randomly assigned to receive either CBD plus standard treatment or standard treatme…

This study looks at the genes and social factors that influence breast and prostate cancer in people of African descent. Researchers will collect blood and tumor samples from 1500 Black patients across the US, Africa, and the Caribbean. The goal is to find genetic changes and und…