Fox Chase Cancer Center

This early-phase trial tests a combination of two drugs, neratinib and fam-trastuzumab deruxtecan (Enhertu), in people with advanced stomach, esophageal, or other gastrointestinal cancers that have a specific marker called HER2. The study aims to find the safest dose and see if t…

Researchers are testing whether a chemotherapy combination called gemcitabine and carboplatin can help people with advanced urothelial cancer whose disease has worsened after treatment with enfortumab vedotin and pembrolizumab. The trial enrolls about 55 participants who receive …

This study tests whether combining mycophenolate mofetil (MMF) with prednisone can better treat liver inflammation caused by checkpoint inhibitor cancer drugs. The trial includes adults with moderate to severe immune-related hepatitis who need to pause their cancer therapy. The m…

This trial asks whether using a device that measures a person's actual energy needs (indirect calorimetry) is a better way to prescribe parenteral nutrition—liquid food given through a vein—for adults with cancer who cannot eat enough by mouth. Half of the participants will have …

This Phase II trial is testing whether a different dosing schedule of the drug cabozantinib can reduce side effects while still controlling cancer growth. It includes people with advanced kidney cancer (clear cell or non-clear cell) and neuroendocrine tumors (including carcinoid)…

This study tests whether lower doses of chemotherapy can effectively control lung cancer in patients aged 70+ or those with other health problems. About 280 participants will receive pre-set reduced chemo doses to see if tumors shrink while causing fewer side effects. The goal is…

This early-phase trial tests whether adding an experimental drug called CBL0137 (Curaxin) to standard immunotherapy (ipilimumab and nivolumab) is safe for people with advanced melanoma that has spread. Only 12 participants will be enrolled, and the main goal is to check for side …

This phase II trial is testing whether giving radiation only to the side of the neck where the cancer is found can reduce dry mouth and other side effects in people with HPV-positive oropharynx cancer. About 22 participants will receive radiation (with or without chemotherapy) to…

This early-phase study tests whether adding an experimental drug (CADI-05) to standard immunotherapy (pembrolizumab) can help the immune system better fight advanced head and neck cancer before surgery. About 22 adults with resectable, locally advanced disease will receive both t…

This study tests whether a maintenance drug (pembrolizumab) can help control advanced bladder cancer after an initial 18-week combination treatment. About 97 people who have not had prior therapy for metastatic disease will participate. The goal is to see if this approach improve…

This early-phase study tests whether giving extra, MRI-guided radiation after standard treatment is safe and effective for people with rectal cancer. About 37 participants will first receive standard chemoradiation, then get additional radiation that adjusts every two weeks based…

This early-phase trial tests whether adaptive radiation therapy (ART) can safely deliver higher, more focused radiation doses to pancreatic tumors while protecting nearby organs. Sixteen adults with locally advanced, inoperable pancreatic cancer will receive five treatments over …

This study is testing a new type of radiation therapy called adaptive SBRT for men with intermediate- or favorable high-risk prostate cancer. The goal is to see if it can safely deliver a higher dose of radiation directly to the tumor while avoiding nearby organs, which may reduc…

This Phase I trial tests adaptive stereotactic body radiation (SBRT) for people with cancer that has spread to the abdomen or pelvis. The goal is to safely deliver higher radiation doses to tumors while keeping severe side effects under 10%. Thirty participants will receive this …

This study is testing whether a combined blood and urine DNA test can accurately detect muscle-invasive bladder cancer in patients scheduled for bladder removal surgery. Researchers will compare the test results with the actual findings from surgery. The goal is to see if this no…

This early-phase trial tests whether taking CBD capsules can prevent nerve damage caused by the chemotherapy drug oxaliplatin in people with colorectal cancer. Thirty participants will be randomly assigned to receive either CBD plus standard chemo or chemo alone. The main goal is…

This study looks at whether a prehabilitation program—including physical therapy, dietary advice, and emotional support—given before major cancer surgery can reduce deaths and serious complications within 30 days after the operation. About 180 adults with cancers of the pancreas,…

This study tests whether an educational video and workbook can help gynecologic cancer patients bring up sexual health concerns with their cancer care team. About 200 patients will either receive the video and workbook plus a resource guide, or just the guide alone. Researchers w…

This study tests whether giving iron infusions can improve anemia (low red blood cells) in cancer patients receiving chemotherapy before surgery. About 34 adults with breast, lung, stomach, or urinary cancers will receive iron sucrose infusions. The goal is to raise hemoglobin le…

This study aims to help Asian American cancer patients and their caregivers feel better emotionally and reduce the sense of burden. Researchers will test a program of positive activities designed to boost feelings of independence, skill, and connection. About 186 patient-caregive…

Researchers at Fox Chase Cancer Center are studying whether giving older adults detailed information about their health and physical function changes what they prioritize in cancer treatment. The trial enrolls 100 people aged 65 and older who are starting or considering a new can…