Fondazione Irccs Ca' Granda, Ospedale Maggiore Policlinico

This study aims to find genetic differences that make some people with fatty liver disease develop severe liver damage or cancer. Researchers will analyze DNA from blood and liver tissue of 2880 adults with advanced disease and compare it to controls. The goal is to create better…

This study aims to find genetic causes of cholestatic liver disease in adults whose condition remains unexplained after standard tests. Researchers will use whole-genome sequencing on 60 participants to look for rare gene changes linked to bile flow problems. The goal is to impro…

This study aims to see if a special cell culture system can detect a substance in the blood that causes protein leakage in the urine of people with a kidney condition called nephrotic syndrome. Researchers will compare blood and urine samples from 150 participants—including patie…

This study looks at how genes affect the risk of liver and heart problems in people with fatty liver disease. Researchers will collect genetic and health data from 2,500 blood donors aged 40-65 who are overweight or have related conditions. The goal is to create a genetic risk sc…

This study aims to understand why some people develop a rare, serious liver disease called primary sclerosing cholangitis (PSC). Researchers will create 3D cell models from patient samples to study how specific genetic changes affect bile duct cells. The goal is to identify genet…

This study is looking at whether tiny particles in the blood, called extracellular vesicles, can help predict nerve damage caused by chemotherapy. About 120 adults with certain cancers will give blood samples and answer questions before, during, and after treatment. The goal is t…

This study looks at how a person's genes and their environment (like alcohol use) work together to cause liver cancer in people with alcohol-related liver disease. Researchers will study 1,000 adults to find new genetic variants that increase cancer risk. The goal is to create a …

This study looks at special cells from blood vessels (called ECFCs) in people with von Willebrand disease, acquired von Willebrand syndrome, and healthy volunteers. Researchers want to see how these cells make and release a key clotting protein. The goal is to better understand t…