Federation Francophone De Cancerologie Digestive

This study tests whether giving a powerful chemotherapy (mDCF) before the usual chemoradiation can improve outcomes for people with advanced anal cancer that hasn't spread. About 310 adults with T3-4 or N1 stage disease will be randomly assigned to either standard treatment or th…

This study tests whether giving two targeted drugs (encorafenib and cetuximab) before surgery can shrink tumors in people with a specific genetic mutation (BRAF V600E) in localized colon or upper rectal cancer. About 30 participants will receive the drug combination for a short t…

This study tests whether adding fruquintinib (a drug that cuts off tumor blood supply) to standard chemotherapy (trifluridine/tipiracil) helps people with advanced stomach or gastro-esophageal cancer live longer. About 324 adults who have already tried two or three prior treatmen…

This study enrolls 600 adults with a specific type of advanced colorectal cancer (MSI-H) who are starting immunotherapy as their first treatment. Researchers want to understand why about 20-30% of patients do not respond to the drug pembrolizumab. By identifying these resistance …