Centre Hospitalier St Anne

This Phase 3 trial tests a personalized care plan for 500 young people aged 15-30 with early psychosis. The plan combines cognitive training (using apps and virtual reality) with supplements (vitamin B12, folinic acid, Omega 3, NAC) tailored to each person's needs. The goal is to…

Researchers are testing whether magnetic stimulation of a brain region called the temporo-parietal junction can shorten auditory hallucinations in people with treatment-resistant schizophrenia. Participants receive active or sham stimulation at the moment a hallucination begins, …

This phase 2 trial tests whether adding the antidepressant trazodone to psilocybin can reduce the intense psychedelic effects while keeping the mood-lifting benefits. 112 adults with treatment-resistant depression will receive either psilocybin alone, psilocybin plus a low or hig…

This pilot study explores whether low-intensity ultrasound waves aimed at specific brain areas can ease symptoms in people with treatment-resistant depression. Thirty-two adults aged 18 to 75 who have not responded to at least two antidepressant treatments will receive personaliz…

This pilot study tests whether screening and treating sleep disorders during tobacco or cannabis cessation therapy helps people stay abstinent longer. 80 participants will either get usual care or extra sleep-focused care. The study follows them for 6 months to see if addressing …

This study tests whether wearing blue-blocking glasses can reduce manic symptoms in people with bipolar 1 disorder during a manic episode. Twenty-five hospitalized adults will wear the glasses for 7 days. Researchers will check if the glasses are easy to use and if they help impr…

This study is looking for biological markers in the body that might predict how well people with treatment-resistant psychiatric disorders—like schizophrenia, depression, bipolar disorder, OCD, and catatonia—respond to new treatments. Researchers will collect blood, stool, cerebr…

Researchers are studying whether voice recordings can show if people with schizophrenia are taking their antipsychotic medication. About 200 participants will use a smartphone app to record speech interviews and give blood samples over six months. The goal is to see if speech pat…

Researchers want to know whether mathematical models of mood, combined with brain imaging and daily smartphone check-ins, can describe mood in a way that matters for depression and bipolar disorder. The study enrolls three groups of 96 people each: those with depression, those wi…

Deep brain stimulation uses implanted electrodes to send electrical pulses to specific brain regions, and doctors are still working out how to tune it for each patient. This study records brain activity while adults with neurological or psychiatric conditions perform cognitive an…

This pilot study will test a tablet-based tool called TICOALA that checks language comprehension and learning in children aged 3 to 7 who visit a child psychiatry service in Paris. Researchers want to see if children, parents, and clinicians find the tool acceptable and if a larg…

This observational study looks at how controlled sensory stimulation, such as music, changes brain activity in people with epilepsy and healthy volunteers. Researchers will measure brain networks and track anxiety and depression symptoms. The goal is to better understand brain fu…

This study tests whether offering three early phone calls and five online support group sessions to adults with eating disorders (like anorexia or bulimia) during their wait for specialized care can reduce the number of people who drop out before starting treatment. About 215 adu…

This study is looking at how people with conditions like schizophrenia, bipolar disorder, depression, and neurological diseases (such as Alzheimer's or stroke) perform on computer-based thinking tests. The goal is to create a detailed map of cognitive strengths and weaknesses acr…

This study looks at how a low-dose drug that increases noradrenaline (a brain chemical) affects learning in 160 healthy adults. Participants will take either the drug or a placebo and perform tasks that measure how they learn from new information. The goal is to better understand…

This study looks at how myelin, the insulation around nerve fibers, influences thinking and problem-solving in people aged 10 to 25. Researchers will use MRI scans and cognitive tests to measure brain structure and mental skills. The goal is to better understand normal brain deve…