Ann & Robert H Lurie Children's Hospital Of Chicago

This early-phase trial is testing a new vaccine (rHSC-DIPGVax) made from pieces of tumor proteins, given together with two immunotherapy drugs (balstilimab and zalifrelimab), in children with DIPG or diffuse midline glioma. The goal is to see if the combination is safe and tolera…

This study tests whether a mobile app and digital sensors, along with support from an asthma coordinator, can help children aged 4-17 with persistent or uncontrolled asthma. 80 parent-child pairs will be split into two groups: one gets the app and sensors with remote monitoring s…

This study tests if adding a second ligament repair (ALL) to standard ACL surgery in children lowers the chance of the ACL graft failing over time. About 240 kids aged 18 and under who need ACL surgery will be randomly assigned to get ACL repair alone or with the extra ALL repair…

This study tests a special dye called Cytalux that makes cancer cells glow under near-infrared light. Surgeons use it during lung surgery to find and remove hard-to-see tumors in teens (ages 6-17) with bone cancer that has spread to the lungs. The goal is to see if the dye helps …

This study tests whether taking part in racial justice activism can prevent depression and reduce physical stress in Black and Latinx young people aged 15-20. Researchers will measure mood, stress hormones, and health markers over two years. The goal is to see if activism can be …

This study looks at whether a 'watch and wait' approach to antibiotics can safely reduce unnecessary use in children with mild pneumonia. About 2,000 children will be randomly assigned to either get antibiotics right away or wait 72 hours to see if they improve on their own. The …

This study tests a program called H-HOPE for babies born with birth defects who need surgery soon after birth. The program includes special care and support to help with feeding, growth, and brain development, while also improving parents' mental health. About 40 babies and their…

This study looks at why teens with obesity often regain weight after losing it. Researchers think hormones that control appetite might be involved. Over 35 weeks, 260 teens will follow a meal replacement plan and then be monitored for weight regain. The goal is to understand the …

This study looks at whether extra follow-up support for caregivers can help after a child's mental health emergency room visit. About 75 caregivers of youth aged 10-17 who visited the ER for suicidal thoughts or behaviors will be randomly assigned to receive usual care, follow-up…

This study looks at whether a Fitbit can help doctors catch infections early in children who had surgery for a burst appendix. About 500 kids aged 3 to 18 will wear a Fitbit after surgery. Researchers will track their activity, heart rate, and sleep to see if changes can predict …

This study asks families of children with cancer to donate their child's tumor tissue after death. Researchers will use the tissue to create lab models and share samples with other scientists. The goal is to better understand pediatric cancers and develop new treatments. Up to 15…

This study is creating a registry of up to 500 people with eosinophilic gastrointestinal disorders (EGIDs), including eosinophilic esophagitis, gastroenteritis, and colitis. Researchers will collect information from medical records, questionnaires, and tissue samples taken during…

This early-stage study looks at whether it's possible to run a larger trial of empagliflozin, a diabetes drug, in 40 children with chronic kidney disease. Participants are randomly assigned to take the drug or continue usual care for 3 months. Researchers will check if the drug i…