Teen weight loss mystery: hormones may be the culprit behind regain
NCT ID NCT05125822
First seen Jun 04, 2026 · Last updated Jun 23, 2026 · Updated 6 times
Summary
This study looks at why teens with obesity often regain weight after losing it. Researchers think hormones that control appetite might be involved. Over 35 weeks, 260 teens will follow a meal replacement plan and then be monitored for weight regain. The goal is to understand the body's response to weight loss, not to test a new drug.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Ann & Robert H Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Meal replacement and lifestyle modification
What this could lead to
If successful, this could help explain why weight regain happens after dieting, pointing toward better long-term weight management strategies.
What could go wrong
This is an observational study, not a treatment trial. It may not lead to a direct solution, and results may not apply to all teens with obesity.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.