New vaccine combo aims to fight deadly childhood brain tumors
NCT ID NCT04943848
First seen Mar 24, 2026 · Last updated Apr 28, 2026 · Updated 2 times
Summary
This early-phase trial tests a new vaccine (rHSC-DIPGVax) combined with two immunotherapy drugs (BALSTILIMAB and ZALIFRELIMAB) in children with diffuse intrinsic pontine glioma (DIPG) or diffuse midline glioma (DMG). The vaccine is designed to help the immune system recognize and attack tumor cells. The study aims to find a safe dose and see if the combination can slow tumor growth. About 36 children who have completed radiation therapy will take part.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Ann and Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
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Children's Health Orange County (CHOC)
RECRUITINGOrange, California, 92868, United States
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Dana-Farber Boston Children's Cancer and Blood Disorders Center
RECRUITINGBoston, Massachusetts, 02215, United States
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